冰片对血眼屏障通透性的影响

目的:研究冰片对家兔血眼屏障通透性的影响。方法:将42只家兔随机分为实验组和对照组,每组21只。实验组给予冰片(0.8g/kg)灌胃,对照组等体积溶媒灌胃,给药后15min耳缘静脉注射20g/L伊文思蓝(EB),分别经5,15,30,45,60,90,120min取房水及玻璃体。采用荧光分光光度法检测房水及玻璃体中的EB浓度。结果:与对照组相比,实验组房水和玻璃体中EB含量更高。结论:冰片可提高家兔血眼屏障的通透性,是一种有效促进药物透过血眼屏障的穿透促进剂。这将为某些内眼疾病的药物治疗提供新方法。

Effect of borneol in improving permeability of blood-ocular barrier

AIM:To observe the effect of borneol on the permeability of blood-ocular barrier in rabbits.METHODS:A total of 42 rabbits were randomly divided into experimental group and control group(21 animals in each group).Rabbits were injected(i.v)with 2% Evan's Blue(EB)after 15 minutes of intragastric administration of borneol(0.8g/kg)or dissolvant.Aqueous humor and vitreous humor were collected at 5,15,30,45,60,90,120 minutes.The concentration of EB in aqueous humor and vitreous humor was determined by fluorescent quantitive methods.RESULTS:In experimental group,the concentration of EB in aqueous humor and vitreous humor increased significantly compared with those of control group.CONCLUSION:For borneol can enhance the permea-bility of blood-ocular barrier to EB,it is a promising useful penetration enhancer,which can improve permeability of drug through blood-ocular barrier,and accordingly provide a novel pathway to the medicine treatment of certain internal ophthalmopathy.