长春地区慢性胃病患者幽门螺杆菌感染状况调查

目的通过对本地区慢性胃病患者幽门螺杆菌（H.pylori）感染状况调查,了解本地区流行病学特点,为进一步阐明其与慢性胃病发生发展的关系提供理论依据。方法采用ELISA方法测定血清H.pyloriIgG抗体及CagA抗体;采取胃粘膜活检组织进行快速尿素酶试验,调查H.pylori感染情况,分析其与各种疾病的关系。结果1180例慢性胃病患者H.pylori感染率为67.11%,复合性溃疡、十二指肠溃疡、胃溃疡及慢性萎缩性胃炎感染率分别为90.9%、84.57%、83.96%和80.24%。与慢性浅表性胃炎相比差异有显著性。消化性溃疡、慢性萎缩性胃炎、胃癌和胃息肉患者血清Hp-CagA抗体的阳性率明显高于慢性浅表性胃炎（P〈0.05）。结论本地区慢性胃病患者H.pylori感染率高与多数地区的普通人群,H.pylori感染者尤其是CagA阳性者,更易发生慢性萎缩性胃炎、消化性溃疡及胃癌。

Investigation on H.pylori infection in chronic gastric desease patients from Changchun area

Objective To investigate the status of H. pylori infection in native patients with chronic gastric disease, to make out the epidemiologieal features of this area and provide rationale for shedding lignt on the association between H. pylori and chronic gas- tric disease.Methods ELASA assays were used to detect the serum level of anti-H, pylori-CagA. Gastric mucosa were taken and rapid uricase tests were used to identify H. pylori infection in order to infer the association between H. pylori infection and the occurrence of peptic diseases. Results Infection rate of H. pylori in 1180 patients with chronic gastric disease was 67.11%, amongst the infection rate of compound ulcer was 90.9% ,and that of dudenal ulcer,gastric ulcer and chronic atrophic gastritis was 84.57% ,83. 96 % and 80.24%, respectively, appeared significant difference when compared with chronic superficial gastritis. Serum level of anti- H. pylori-CagA in patients with peptic tdcer, chronic atrophic gastritis, gastric cancer and gastric polypus were higher than that of superficial gastritis（ P 〈 0.05）. Conclusion H. pylori infection rates of patients with chronic gastric disease were higher than those of ordinary people. H. pylori infectioner especially with anti-H, pylori-CagA were more likely to complicate chronic atrophic gastritis, peptic ulcer and gastric cancer.