| 生脉注射液对损伤心肌细胞乳酸脱氢酶及心肌细胞超微结构的影响 |
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| 引用本文： | 蔡青,荣烨之,黄国芳,韩玉升,陈玉英.生脉注射液对损伤心肌细胞乳酸脱氢酶及心肌细胞超微结构的影响[J].中国中西医结合杂志,1991(5):286-288,262. |
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| 作者姓名： | 蔡青 荣烨之 黄国芳 韩玉升 陈玉英 |
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| 作者单位： | 上海第二医科大学心肌疾病研究室，上海第二医科大学心肌疾病研究室，上海第二医科大学心肌疾病研究室，上海第二医科大学生物物理教研室，上海第二医科大学生物物理教研室 上海 200092，上海 200092，上海 200092，上海 200092，上海 200092 |
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| 基金项目： | 上海市青年自然科学基金资助 |
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| 摘 要： | 本实验运用体外培养心肌细胞,观察了中药生脉注射液对阿霉素引起心肌细胞损伤时,心肌细胞内乳酸脱氢酶释放及超微结构的影响。结果表明,生脉注射液30、100、300mg/L 对阿霉素1 mg/L 作用4 h 引起的培养心肌细胞乳酸脱氢酶释放没有影响;对其引起的心肌细胞超微结构损伤也无改善作用。结果提示:生脉注射液对阿霉素引起的心肌损害的保护作用,可能是在整体情况下产生的。
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| 关 键 词： | 生脉注射液 阿霉素 乳酸脱氢酶 超微结构 |
Protective Effect of Sheng Mai Injection on Myocardial Injury Induced by Adriamycin in Cultured Myocardial Cells |
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| Authors: | Cai Qing |
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| Abstract: | The effect of Sheng Mai injection(SMI)on adriamycin-induced cardiotoxicity in cultured myocardial cells was examined.Adriamycin treatment(1 mg]L)for 4 h of culture age,increased remarkably the leakage of lactate dehydrogenase(LDH)from the myocardial cells,and induced the damage of ultrastructure.SMI(30 my/L,100 my/L,300 mg/L)had no effects on these changes induced by adriamycin.The results showed that SMI had no direct protective effect on adriamycin cardiotoxicity in cultured myocardial cells.It's protective effect on adriamycin cardiotoxicity seems to be in whole body level,the mechanism of which was relating to the metabolism of the drug in organism,and is worthy of further research. |
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| Keywords: | Sheng Mai injection adriamycin lactate dehydrogenase ultrastructure |
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