Plasmid-mediated fluoroquinolone efflux pump gene, qepA, in Escherichia coli clinical isolates in Korea |
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| Authors: | Eun Sil Kim Jin-Yong Jeong Sang-Ho Choi Sang-Oh Lee Sung-Han Kim Mi-Na Kim Jun Hee Woo Yang Soo Kim |
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| Affiliation: | aDepartment of Infectious Diseases, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea;bCenter for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul 138-736, Republic of Korea;cDepartment of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea |
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| Abstract: | The qepA gene was detected in 4 (0.6%) of 621 nonduplicate Escherichia coli clinical isolates collected from blood cultures in Korea. Three of the 4 qepA-positive isolates contained blaCTX-M-14 and/or blaTEM-1 genes, but not the E8700 isolate. The qepA gene was successfully transferred and conferred resistance to hydrophilic quinolones, such as norfloxacin and ciprofloxacin, in the recipient. The gene was located in part of IS26. Two isolates were linked to the truncated rmtB gene. |
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| Keywords: | Plasmid-mediated quinolone resistance QepA Extended-spectrum β -lactamases |
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