食管胃交界部肿瘤的最新研究进展

近年来，食管胃交界部肿瘤（carcinoma of esophagogastric junction，CEG）发病率明显升高，但是在其分类、病因、治疗原则等很多方面存在争议，争议源于贲门解剖学位置和结构的复杂性。目前学术界普遍采用的是Siewert分类法，将肿瘤分为三类：AEGⅠ型、AEGⅡ型和AEGⅢ型。胃食管返流性疾病、食管裂孔疝、幽门螺旋杆菌、饮食、生活习惯和药物等都是导致CEG肿瘤发生重要因素，这些因素导致上皮细胞在基因和染色体水平出现紊乱，最终促使正常细胞演变为肿瘤细胞，但是具体的机制还有待深入研究和探讨。本文对上述问题的最新研究进展进行综述。

Recent advances in carcinoma of the esophagogastric junction

Incidence rate of carcinoma of the esophagogastric junction （CEG） has obviously risen. However, the classification, etiopathogenisis and therapeutic principle of CEG are still in dispute because of complexity of anatomical location and structure of the cardia. At present, Siewert＇s classification of CEG,which divided CEG into three separate subtypes： Type Ⅰ,Type Ⅱ and Type Ⅲ,has come into popular use by many scholars. The important factors resuiting in CEG include gastroesophageal reflux disease, esophageal hiatal hernia, helicobacter pylori, dietary factors, living habit and drug. These factors lead to gene and chromosome abnormalities of epithelial cell, finally result in the transformation of normal human cells into tumor cells. However,the mechanisms are still under dispute or study. The article reviews the recent advances in this field.