Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines |
| |
| Authors: | Dan Turner Arie Levine Johanna C Escher Anne M Griffiths Richard K Russell Axel Dignass Jorge Amil Dias Jiri Bronsky Christian P Braegger Salvatore Cucchiara Lissy de Ridder Ulrika L Fagerberg Séamus Hussey Jean-Pierre Hugot Sanja Kolacek Kaija Leena Kolho Paolo Lionetti Anders Pærregaard Alexander Potapov Risto Rintala Daniela E Serban Annamaria Staiano Brian Sweeny Gigi Veerman Gabor Veres David C Wilson Frank M Ruemmele |
| |
| Affiliation: | *Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem ?Wolfson Medical Center, Tel-Aviv University, Tel-Aviv, Israel ?ErasmusMC-Sophia Children's Hospital, Rotterdam, The Netherlands §The Hospital for Sick Children, University of Toronto, Toronto, Canada ||Yorkhill Hospital, Glasgow, UK ?Agaplesion Markus Hospital, Frankfurt/Main, Germany #Hospital S. Jo?o, Porto, Portugal **2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic ??University Children's Hospital, Zurich, Switzerland ??Pediatric Gastroenterology and Liver Unit, "La Sapienza" University, Rome, Italy §§Centre for Clinical Research, V?stmanland County Hospital, V?ster?s, Karolinska Institutet, Stockholm, Sweden ||||Our Lady's Children's Hospital, Crumlin Dublin, Ireland ??Univ Paris-Diderot-Sorbonne Paris-Cité, Hopital Robert Debré, Paris, France ##Children's Hospital, Medical Center "Sestre Milosrdnice," Zagreb University Medical School, Croatia ***Children's Hospital, Helsinki, University Central Hospital and University of Helsinki, Finland ???University of Florence, Meyer Hospital, Florence, Italy ???Hvidovre University Hospital, Copenhagen, Denmark §§§Children's Health Russian Academy of Medical Sciences, Moscow, Russia ||||||||||University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania ???University of Naples "Federico II," Italy ###UZ Brussels, Belgium ****Semmelweis University, Budapest, Hungary ????Child Life and Health, University of Edinburgh, UK ????Université Paris Descartes, Sorbonne Paris Cité, APHP, H?pital Necker Enfants Malades, Paris, France. |
| |
| Abstract: | BACKGROUND AND AIMS:: Pediatric ulcerative colitis (UC) shares many features with adult-onset disease but there are some unique considerations; therefore, therapeutic approaches have to be adapted to these particular needs. We aimed to formulate guidelines for managing UC in children based on a systematic review (SR) of the literature and a robust consensus process. The present article is a product of a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). METHODS:: A group of 27 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to ESPGHAN and ECCO members. A list of 23 predefined questions were addressed by working subgroups based on a SR of the literature. RESULTS:: A total of 40 formal recommendations and 68 practice points were endorsed with a consensus rate of at least 89% regarding initial evaluation, how to monitor disease activity, the role of endoscopic evaluation, medical and surgical therapy, timing and choice of each medication, the role of combined therapy, and when to stop medications. A management flowchart, based on the Pediatric Ulcerative Colitis Activity Index (PUCAI), is presented. CONCLUSIONS:: These guidelines provide clinically useful points to guide the management of UC in children. Taken together, the recommendations offer a standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient is unique. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
