| 海洛因成瘾者后扣带回皮层在静息态及毒品线索诱导任务中的功能异常 |
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| 引用本文： | 李强,杨伟川,王亚蓉,黄玉芳,李玮,朱佳,张毅,赵励彦,秦伟,袁凯,Karen M. von Deneen,王玮,田捷. 海洛因成瘾者后扣带回皮层在静息态及毒品线索诱导任务中的功能异常[J]. 中华医学杂志(英文版), 2013, 126(4): 734-739 |
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| 作者姓名： | 李强 杨伟川 王亚蓉 黄玉芳 李玮 朱佳 张毅 赵励彦 秦伟 袁凯 Karen M. von Deneen 王玮 田捷 |
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| 作者单位： | [1]Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi＇an, Shaanxi 710038, China [2]Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi＇an, Shaanxi 710071, China [3]National Institute on Drug Dependence, Peking University, Beijing100191, China |
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| 基金项目： | This research was supported-in part by grants from the National Natural Science Foundation of China （Nos. 30870685, 81071142, 81071143 and 81201081） and the Development Project of Science and Technology of Shaanxi Province （Nos. 2008K12-02, 2009K01-65, 2010K16-03-01 and 2010K16-03-02）. |
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| 摘 要： | Background Previous animal and neuroimaging studies have demonstrated that brain function in heroin addicted users is impaired.However,the posterior cingulate cortex (PCC) has not received much attenti...
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| 关 键 词： | 海洛因 静息态 扣带回 用户 状态 皮质 功能磁共振成像 功能性磁共振成像 |
Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task |
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| LI Qiang , YANG Wei-chuan , WANG Ya-rong , HUANG Yu-fang , LI Wei , ZHU Jia. Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task[J]. Chinese medical journal, 2013, 126(4): 734-739 |
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| Authors: | LI Qiang YANG Wei-chuan WANG Ya-rong HUANG Yu-fang LI Wei ZHU Jia |
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| Affiliation: | 1. Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi 710038, China
2. Department of Radiology, 422 Military Hospital, Zhanjiang,Guangdong 524000, China |
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| Abstract: | Background Previous animal and neuroimaging studies have demonstrated that brain function in heroin addicted users is impaired.However,the posterior cingulate cortex (PCC) has not received much attention.The purpose of this study was to investigate whether chronic heroin use is associated with craving-related changes in the functional connectivity of the PCC of heroin addicted users.Methods Fourteen male adult chronic heroin users and fifteen age and gender-matched healthy subjects participated in the present study.The participants underwent a resting-state functional magnetic resonance imaging (fMRI) scan and a cue-induced craving task fMRI scan.The activated PCC was identified in the cue-induced craving task by means of a group contrast test.Functional connectivity was analyzed based on resting-state fMRI data in order to determine the correlation between brain regions.The relationship between the connectivity of specific regions and heroin dependence was investigated.Results The activation of PCC,bilateral anterior cingulate cortex,caudate,putamen,precuneus,and thalamus was significant in the heroin group compared to the healthy group in the cue-induced craving task.The detectable functional connectivity of the heroin users was stronger between the PCC and bilateral insula,bilateral dorsal striatum,right inferior parietal Iobule (IPL) and right supramarginal gyrus (P＜0.001) compared to that of the healthy subjects in the resting-state data analysis.The strength of the functional connectivity,both for the PCC-insula (r=0.60,P ＜0.05) and for PCC-striatum (r=0.58,P＜0.05),was positively correlated with the duration of heroin use.Conclusion The altered functional connectivity patterns in the PCC-insula and PCC-striatum areas may be regarded as biomarkers of brain damage severity in chronic heroin users. |
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| Keywords: | heroin craving resting-state posterior cingulate cortex functional magnetic resonance imaging |
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