轻度血管性认知障碍患者血清同型半胱氨酸超敏C反应蛋白与颈动脉狭窄的关系

目的探索轻度血管性认知障碍（MCI）患者血清同型半胱氨酸（HCY）、超敏C反应蛋白（hs-CRP）与颈动脉狭窄的关系。方法以我院2011年10月至2013年10月收入的98例轻度血管性认知障碍患者为研究对象,经颈部血管彩超诊断颈动脉狭窄的58例患者为观察组,同期住院的40例非认知障碍性脑血管病患者为对照组,两组进行HCY和hs-CRP水平测定。结果 98例MCI患者颈动脉狭窄为59.18%,其中轻度狭窄为16.33%,中度狭窄为19.39%,重度狭窄为23.47%;有血流动力学改变的中重度狭窄为38.78%;无狭窄为40.82%。对照组40例患者,颈动脉狭窄为12.50%,其中轻度狭窄为10.00%,中度狭窄为2.50%,有血流动力学改变的为2.50%,各项检出指标观察组均显著高于对照组,其差异具有统计学意义,P〈0.05;轻、中、重度颈动脉狭窄患者的HCY、hs-CRP水平分别与对照组比较,差异均具有统计学意义,P〈0.05;HCY水平3组间比较,均为差异有统计学意义,P〈0.05;hs-CRP水平,轻度狭窄组与中度狭窄组相比差异无统计学意义P〉0.05,重度狭窄组与轻、中度狭窄组相比差异有统计学意义,P〈0.05。结论高HCY水平、高hs-CRP水平以及颈动脉狭窄与MCI密切相关,探究三者的相关性可为未来临床确定新的治疗靶点提供铺垫作用。

Relationship between serum homocysteine high-sensitivity C reactive protein and carotid artery stenosis of patients with mild vascular cognitive impairment

Objective To explore the mild vascular cognitive impairment（ MCI） patients with serum homocysteine（ HCY）,Chao Min C reactive protein（ hs-CRP） and carotid artery stenosis. Methods 98 cases of mild vascular cognitive impairment patients in our hospital in 2011 October ~ 2013 year in October income as the object of study,the diagnosis of 58 cases of neck vascular color Doppler ultrasound of carotid artery stenosis were treated as observation group,of 40 inpatients in patients without cognitive impairment of cerebral vascular disease as control group,two groups HCY and hs-CRP levels determination of. Results 98 cases of patients with carotid artery stenosis was 59. 18% MCI,including mild stenosis 16. 33%,moderate stenosis,severe stenosis were19. 39%,23. 47%; a hemodynamic changes in severe stenosis was 38. 78; no stenosis was 40. 82%. A control group of 40 patients,carotid artery stenosis was 12. 50%,including mild stenosis 10%,moderate stenosis was2. 50%,with the hemodynamic changes of the detection index is 2. 50%,the observation group were significantly higher than those in control group,the difference was significant,P ＆lt; 0. 05; light,heavy,in the degree of carotid artery stenosis in patients with HCY the level of hs-CRP,respectively,compared with the control group,the differences were statistically significant,P ＆lt; 0. 05; HCY levels between the 3 groups,are statistically significant differences,P ＆lt; 0. 05; hs-CRP,mild stenosis group and the moderate stenosis group there was no significant difference of P ＆gt; 0. 05,severe stenosis group and light,moderate stenosis group have significant difference compared,P ＆lt; 0. 05. Conclusions High HCY level,high s-CRP levels and carotid artery stenosis is closely related with MCI,correlation between the three can provide a foreshadowing role for clinical determine the future of new therapeutic targets.