| 注射性肌挛缩症的病理改变与细胞膜标志酶及胰岛素受体变化的研究 |
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| 引用本文： | 刘敏,彭明惺,胡廷泽,陈曼玲,郎诗民.注射性肌挛缩症的病理改变与细胞膜标志酶及胰岛素受体变化的研究[J].四川大学学报(医学版),1993(3). |
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| 作者姓名： | 刘敏 彭明惺 胡廷泽 陈曼玲 郎诗民 |
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| 作者单位： | 华西医科大学附属第一医院小儿外科
(刘敏，彭明惺，胡廷泽)，华西医科大学生物化学及分子生物学研究所激素受体研究室
(陈曼玲)，华西医科大学附属第一医院小儿外科(郎诗民) |
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| 摘 要： | 以注射性肌挛缩症动物模型为过度愈合范例,对注射性肌挛缩症的病理改变及其与细胞膜标志酶及胰岛素受体的变化进行动态观察。结果该病病理改变为结缔组织过度增生,属过度愈合范畴。在注射药物1周内,以横纹肌细胞坏死、炎性细胞浸润为主,未见成纤维细胞增生及胶原纤维沉积,细胞膜标志酶活性及胰岛素受体特异性结合率均低;1周后伴随成纤维细胞增生、胶原纤维沉积不断增加的同时,细胞膜标志酶及胰岛素受体亦逐渐增高。以上结果表明,过度愈合的发生可能与细胞膜标志酶及胰岛素受体的变化有关。
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| 关 键 词： | 注射性肌挛缩症 5′-核苷酸酶 胰岛素受体 过度愈合 |
Pathology of Muscle Contracture Caused by Injection and Activity of Phosphochesterase and Insulin Receptor |
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| Liu Min,Peng Mingxing,Hu Tingze,Chen Manling Lang Shimin.Pathology of Muscle Contracture Caused by Injection and Activity of Phosphochesterase and Insulin Receptor[J].Journal of West China University of Medical Sciences,1993(3). |
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| Authors: | Liu Min Peng Mingxing Hu Tingze Chen Manling Lang Shimin |
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| Institution: | Liu Min,Peng Mingxing,Hu Tingze,Chen Manling Lang Shimin Department of Pediatric Surgery,The First Affiliated Hospital |
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| Abstract: | The animal model ofmuscle contracture caused by injection wasset up in the experiment. We used themodel for excessive healing studies andresearched the changes in its pathology,and activity of phosphochesteraseand insulin receptor in this model. Theexperimental results revealed that thepathologic changes belonged to excessiveproliferation of connective tissue (exces-sive healing). When occurred muscledegeneration, infiltration of inflammatorycells, proliferation of fibroblasts anddescending of collegen fibers, the activitylevel phosphochesterase and insulinreceptor became higher. The excessivehealing occurrence may have somethingto do with the changes of phosphochester-ase and insulin receptor. |
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| Keywords: | Muscle contracture Caused by injection Phosphochesterase Insulin receptor Excessive healing |
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