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| 多巴胺D2受体调控睡眠-觉醒研究进展 | |
| 引用本文： | 许奇,曲卫敏,黄志力. 多巴胺D2受体调控睡眠-觉醒研究进展[J]. 中国临床药理学与治疗学, 2010, 15(4): 361-366 |
| 作者姓名： | 许奇 曲卫敏 黄志力 |
| 作者单位： | 1. 复旦大学医学神经生物学国家重点实验室,上海,200032 2. 复旦大学上海医学院药理学系,上海,200032 3. 复旦大学医学神经生物学国家重点实验室,上海,200032;复旦大学上海医学院药理学系,上海,200032 |
| 基金项目： | 国家自然科学基金，国家"重大新药创制"科技重大专项，上海市科委基金，上海市重点学科建设项目 |
| 摘 要： | 脑内多巴胺（dopamine,DA）参与觉醒相关的运动、认知和奖赏等行为调控。DA能神经元主要位于黑质致密部和腹侧被盖区。DA受体（receptor,R）包括：D1R、D2 R（D2S和D2L）、D3R、D4R和D5R五种亚型。中枢神经内D1R和D2R数目占绝对优势,D2R对内源性DA的亲和力显著高于D1R。近年来,药理学和基因剔除动物等研究发现：D2R是维持觉醒的重要受体,本文综述其研究进展。 |
| 关 键 词： | 多巴胺 D2受体 睡眠 觉醒 基因剔除小鼠 |
Progress in sleep-wake regulation of dopamine D2 receptor |
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| XU Qi,QU Wei-min,HUANG Zhi-li. Progress in sleep-wake regulation of dopamine D2 receptor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 361-366 | |
| Authors: | XU Qi QU Wei-min HUANG Zhi-li |
| Affiliation: | XU Qi~1,QU Wei-min~2,HUANG Zhi-li~(1,2) 1 State Key Laboratory of Medical Neurobiology,2 Department of Pharmacology,Shanghai Medical College of Fudan University,Shanghai 200032,China |
| Abstract: | Dopamine(DA) modulates diverse wake-related behaviors including movement,reward, and cognition.Dopaminergic neurons are located in the substantia nigra pars compacta and ventral tegmental area.There are five distinct DA receptors(R):D_1R,D_2R(D_(2S)R and D_(2L)R), D_3R,D_4R and D_5R in the central nervous system, in which D_1R and D_2R are majorly expressed. The affinity of D_2R for endogenous DA is significantly higher than that of D_1R.Re- cently,studies by pharmacological and gene knock-out animals revea... |
| Keywords: | Dopamine D_2 receptor Knockout mice Sleep Wake |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |