Association of restless legs syndrome,pain, and mood disorders in parkinson's disease |
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Authors: | Abdul Qayyum Rana Abdul Rehman M Qureshi Ajantha Jesudasan Kevin K Hafez Mohammad A Rana |
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Institution: | 1. Parkinson's Clinic of Eastern Toronto and Movement Disorders Centre, Toronto, Canada;2. University of Toronto at Scarborough, 1264 Military Trail, Toronto, Canada;3. University of Calgary—Department of Family Medicine, Sheldon M. Chumir Health Centre, Calgary, Alberta, Canada, and;4. James Cook University—Faculty of Medicine and Dentistry, Townsville Qld, Australia |
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Abstract: | Purpose/Aims: The objectives of the study were to analyze the association between Parkinson's disease and restless legs syndrome, and to explore the relationship between mood disorder comorbidity (anxiety and depression), pain, and restless legs syndrome. Methods: This study included 123 Parkinson's disease patients and 123 non-Parkinson's disease patients matched for age and gender, and evaluated for anxiety severity, depression severity, pain severity, pain interference, pain disability, and restless legs syndrome prevalence. This was performed using semi-structured interviews and a neurological examination through the restless legs syndrome diagnostic criteria and the following inventories; Hospital Anxiety and Depression Scale, Brief Pain Inventory, and Pain Disability Index. Results: Parkinson's disease patients had significantly greater anxiety severity, depression severity, pain severity, pain interference, pain disability, and restless legs syndrome prevalence in comparison to controls. In addition, Parkinson's disease patients’ comorbid for anxiety and depression had significantly greater pain severity, pain interference, and pain disability, but not RLS prevalence, in comparison to Parkinson's disease only, Parkinson's disease anxiety, and Parkinson's disease depression patients. Conclusions: Pain interference, pain severity, and pain disability is greater among Parkinson's disease patients with anxiety and depression, in comparison to Parkinson's disease patients without anxiety and depression. On the contrary, the prevalence of restless legs syndrome was not found to be relevant. |
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Keywords: | restless legs syndrome pain mood disorders comorbidity parkinson's disease |
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