| Altofrequency SNPs of mitochondrial DNA in 26 Han Chinese |
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| 作者姓名： | 罗勇军 高文祥 高钰琪 陈建 谭小玲 刘昕 陈海华 |
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| 作者单位： | Department of Pathophysiology and High Altitude Physiology College of High Altitude Military Medicine Third Military Medical University，Department of Pathophysiology and High Altitude Physiology College of High Altitude Military Medicine，Third Military Medical University，Department of Pathophysiology and High Altitude Physiology College of High Altitude Military Medicine，Third Military Medical University，Department of Pathophysiology and High Altitude Physiology College of High Altitude Military Medicine，Third Military Medical University，Department of Pathophysiology and High Altitude Physiology College of High Altitude Military Medicine，Third Military Medical University，Department of Immunology College of Basic Medicine，Third Military Medical University，Center for Disease Control and Prevention PLA Chengdu Military Area Command，Chongqing 400038，China，Chongqing 400038，China，Chongqing 400038，China，Chongqing 400038，China，Chongqing 400038，China，Chongqing 400038，China，Chengdu 610021，China |
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| 摘 要： | Objective, To explore the possible mitochondrial DNA （mtDNA） polymorphism in Han Chinese. Methods： The complete mitochondrial genome of 26 unrelated healthy Han Chinese were extracted and sequenced. Results： The mtDNA nucleotide sites （2 706, 7 028, 8 860, 11 719, and 15 326） were found totally different from the Revised Cambridge Reference Sequence （rCRS）. These single nucleotide polymorphisms （SNPs） were 2 706 A→G, 7 028 C→T, 8 860 A→G, 11 719 G→A, 15 326 A→G. Conclusion, These findings provide new insights into the characteristics of Han Chinese mitochondrial genetic diversity.
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| 关 键 词： | 汉族 中国人 线粒体DNA 单核苷酸多态性 SNPS 发生频率 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2007-03-14 |
Altofrequency SNPs of mitochondrial DNA in 26 Han Chinese |
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| LUO Yong-jun,GAO Wen-xiang,GAO Yu-qi,CHEN Jian,TAN Xiao-ling,LIU Xin,CHEN Hai-hua.Altofrequency SNPs of mitochondrial DNA in 26 Han Chinese[J].Journal of Medical Colleges of PLA(China),2007,22(2):67-71. |
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| Authors: | LUO Yong-jun GAO Wen-xiang GAO Yu-qi CHEN Jian TAN Xiao-ling LIU Xin CHEN Hai-hua |
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| Institution: | LUO Yong-jun(Department of Pathophysiology and High Altitude Physiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China)；GAO Wen-xiang(Department of Pathophysiology and High Altitude Physiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China)；GAO Yu-qi(Department of Pathophysiology and High Altitude Physiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China)；CHEN Jian(Department of Pathophysiology and High Altitude Physiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China)；TAN Xiao-ling(Department of Pathophysiology and High Altitude Physiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China)；LIU Xin(Department of Immunology,College of Basic Medicine,Third Military Medical University,Chongqing 400038,China)；CHEN Hai-hua(Center for Disease Control and Prevention,PLA Chengdu Military Area Command,Chengdu 610021,China)； |
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| Abstract: | Objective:To explore the possible mitochondrial DNA (mtDNA) polymorphism in Han Chinese.Methods:The complete mitochondrial genome of 26 unrelated healthy Han Chinese were extracted and sequenced.Results:The mtDNA nucleotide sites (2 706,7 028,8 860,11 719,and 15 326)were found totally different from the Revised Cambridge Reference Sequence (rCRS).These single nucleotide polymorphisms (SNPs) were 2 706 A→G,7 028 C→T,8 860 A→G,11 719 G→A,15 326 A→G.Conclusion:These findings provide new insights into the characteristics of Han Chinese mitochondrial genetic diversity. |
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| Keywords: | Han Chinese mitochondrial DNA single nucleotide polymorphism |
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