十二指肠溃疡患者胃上皮化生与幽门螺杆菌关系的研究

目的 研究十二指肠溃疡患者胃上皮化生和幽门螺杆菌的关系。方法 收集门诊行上消化道胃镜检查确诊的十二指肠溃疡患者70例，另选胃和十二指肠黏膜正常患者55例为对照组。用快速尿素酶法和幽门活组织检查半定量法检测幽门螺杆菌(Hp)，苏木素一伊红染色和Schiff过碘酸染色半定量法检测十二指肠球部胃上皮化生。结果 十二指肠溃疡患者与对照组相比，十二指肠球部胃上皮化生检出率高；十二指肠球部胃上皮化生检出率和评分与胃幽门部Hp的检出率和评分无相关关系。结论 Hp不是十二指肠黏膜胃上皮化生的决定因素，也不是十二指肠黏膜胃上皮化生范围得以扩展的因素。十二指肠溃疡病本身的一些特点是十二指肠黏膜胃上皮化生的主要因素。

Relationship between Helicobacter pylori and gastric metaplasia in duodenal ulcer

Objective To study the association of Helicobacter pylori(Hp) and gastric metaplasia in duodenal ulcer.Methods Upper gastrointestinal endoscopy was performed in 70 patients with duodenal ulcer and 55 controls.Rapid urease test and antral gastric biopsies semiquantitative assessment were used for detection of Hp infection.In order to diagnose duodenal gastric metaplasia in biopsy specimens,hematoxylin eosin and periodic acid Schiff staining method were used.Results Duodenal gastric metaplasia was more frequent in duodenal ulcer patients than in controls (55.9% vs 25%, P <0.05 for Hp positive and 72.7% vs 33.3%, P <0.05 for Hp negative patients).There was no relationship between prevalence and extent of duodenal bulb gastric metaplasia with Hp antral colonization rate and its degree.Conclusion Hp is neither an obligatory factor in the etiology of duodenal gastric metaplasia nor the factor of the extension of already present gastric metaplasia.Duodenal ulcer itself is a key denominator of duodenal gastric metaplasia.