HBV感染产妇乳汁中乙肝病毒标志物检测分析

目的探讨HBV感染产妇产后能否进行母乳喂养。方法选择住院分娩的乙型肝炎产妇321例(肝功能均正常),其中血清HBsAg、HBeAb(+/-)、HBcAb阳性210例为小三阳组,HBsAg、HBeAg、HBcAb均阳性111例为大三阳组。分别留取产后3～5d的初乳进行乳汁乙肝病毒标志物(HBV M)检测。结果两组乳汁中HBsAg、HBeAg、HBcAb、HBV DNA阳性率比较,差异有显著性意义(P<0.05)。结论产妇初乳中HBV DNA阳性及产妇血清中大三阳者(HBsAg、HBeAg、HBcAb阳性)不提倡哺乳;初乳中单纯HBsAg阳性,而HBV DNA为阴性的产妇可以哺乳。

Detection and analysis of hepatitis B virus marker in the parturients with hepatitis B

Objective To study the breast feeding of the parturients with hepatitis B after delivery.Methods 321 parturients with hepatitis B (liver function was normal) were selected and divided into two groups: single positive group(n=210) positive for serum HBsAg and double positive group(n=111) positive for both HBsAg and HBeAg . Hepatitis B virus marker (HBV-M) was detected in the colostrums 3d to 5d after delivery.Results There was very significant difference in the positive rate of HBsAg,HBeAg,HBcAg and HBV DNA in the milk between the two groups (P<0.05).Conclusion In terms of the clinical implication of HBV-M,heparturients with the colostrum positive for HBeAg , HBV-DNA and those with the serum double positive for HBsAg and HBeAg were not suitable for breast feeding.The parturients with the colostrums positive for HBsAg,but negative for HBV DNA were suitable for beast feeding.