人乳头瘤病毒感染与非吸烟女性肺癌关系

目的 探讨人乳头瘤病毒(HPV)感染与非吸烟女性肺癌的相关性,以及HPV感染对脆性组氨酸三联体(FHIT)基因杂合性丢失的影响.方法 采用1:1匹配的病例对照研究方法,应用PCR技术检测肺癌组织与对照组织中HPV-DNA相关序列,同时检测FHIT基因杂合性丢失状况.结果 肺癌组织HPV-E6检出率高于对照组,OR=3.500,高危型HPV感染肺组织中FHIT基因杂合子丢失率较高.同时HPV感染与口服避孕药的使用、烹调油烟暴露及既往肺部疾病史间存在交互作用.结论 高危型HPV感染与女性肺癌的发生有关,HPV感染引发的肺癌可能与基因整合使FHIT基因杂合性丢失有关,同时与口服避孕药的使用、烹调油烟暴露及既往肺部疾病史等存在协同效应.

Relationship between HPV infection and lung cancer in nonsmoking female

Objective To explore the relation between HPV infection and lung cancer in female nonsmoker,and to investigate its relationship with LOH of FHIT gene.Methods Lung cancer specimens and control specimens were examined for the sequences of nucleotide markers for FHIT gene and fragment of HPV DNA by PCR.Results HPVE6 had a higher prevalence in cancertissue than that in normal tissues,OR=3.500.In all 19 cases of HPV infection,there were 15 cases in which the FHIT gene LOH was found,more than that of non infection.HPV infection interacted with some lung cancer risk factors.Conclusion HPV infection contribues to lung cancer in nonsmo king female.LOH of FHIT gene might be involved in carcinogenesis of HPV related lung cancer,and has cooperative effect with other risk factors.