| 南海肥厚肉芝软珊瑚Sarcophyton crassocaule化学成分的研究Ⅲ |
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| 引用本文： | 雷玲芳,胡谷平,刘炳新,邓芸,张翠仙. 南海肥厚肉芝软珊瑚Sarcophyton crassocaule化学成分的研究Ⅲ[J]. 广东医药学院学报, 2014, 0(3): 293-296 |
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| 作者姓名： | 雷玲芳 胡谷平 刘炳新 邓芸 张翠仙 |
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| 作者单位： | [1]广州中医药大学中药学院,广东广州510006 [2]中山大学化学与化学工程学院,广东广州510275 |
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| 基金项目： | 国家自然科学基金（81001370）; 中国科学院海洋生物资源可持续利用重点实验室联合基金（LMB1011002）致谢：感谢中山大学分析测试中心姚俊华、关山越、冯小龙在结构鉴定中给予的支持. |
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| 摘 要： | 目的研究采自中国南海海域的肉芝软珊瑚Sarcophyton crassocaule的化学成分。方法采用硅胶柱层析和HPLC等分离手段从南海肉芝软珊瑚的乙酸乙酯提取部位分离得到单体化合物,采用现代波谱技术、物理常数对照以及化学方法对单体化合物的结构进行研究。结果从肉芝软珊瑚Sarcophyton crassocaule中分离得到4个单体化合物。应用化学方法、物理常数对照和现代波谱分析技术对其结构进行解析,确定为：氢醌双苄醚（1）、N-正十六烷酰基-十八碳-4（E）-烯神经鞘氨醇（2）、Δ4,5（E）,Δ8,9（E）-鞘胺醇-正十六碳酰胺（3）、（2S,3S,4R）-N-2-（1,3,4-三羟基-十八烷基）-十八酰胺（4）。结论化合物1为首次得到的天然氢醌双苄醚类化合物;化合物2-4为神经酰胺类化合物。
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| 关 键 词： | 肉芝软珊瑚 Sarcophyton crassocaule 芳香醚 神经酰胺 结构鉴定 |
Study on the secondary metabolites from the soft coral Sarcophyton Crassocaule of South China Sea |
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| LEI Lingfang,HU Guping,LIU Bingxin,DENG Yun,ZHANG Cuixian. Study on the secondary metabolites from the soft coral Sarcophyton Crassocaule of South China Sea[J]. , 2014, 0(3): 293-296 |
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| Authors: | LEI Lingfang HU Guping LIU Bingxin DENG Yun ZHANG Cuixian |
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| Affiliation: | 1.School of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; 2. School of Chemical and Chemical Engineering Science, Sun Yat-sen University, Guangzhou 510275, China) |
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| Abstract: | Objective To study on the chemical constituents from the soft coral sarcophyton crassocaule of South China Sea.Methods Compounds were isolated by silica gel column chromatography and HPLC.Structures of the compounds were identified on the basis of spectral data,physical constant comparison and chemical methods.Results Four compounds 1-4 were isolated,and their structures were identified as hydroquinone dibenzyl ether（1）,N-[（2S,3R,4E）-1,3-dihydroxy-octadec-4-en-2-yl]palmitamide（2）, N-[（2S,3R,4E,8E）-1,3-dihydroxyoctadeca-4,8-dien-2-yl] palmitamide（3）,N-[（2S,3S,4R）-1,3,4-trihydroxyoctadecan-2-yl]stearamide（4）.Conclusion Compound 1 was firstly isolated as natural product, and compounds 2-4 were ceramides. |
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| Keywords: | Soft coral Sarcophyton crassocaule aromatic ether ceramide structural identification |
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