宫颈上皮内瘤变治疗后高危型HPV的清除趋势

目的：探讨宫颈鳞状上皮内瘤变（CIN）治疗后高危型人乳头瘤病毒（HR-HPV）清除趋势.方法：对2008年10月1日～2009年12月30日在新疆自治区人民医院用第二代杂交捕获（Hybird Capture-2,HC2）法检测HR-HPV阳性,在阴道镜下活检诊断为CIN的90例患者进行高频电波刀宫颈环状电圈切除术（The loop electrosurgical excision procedure,LEEP）或者冷刀锥切术（cold-knife conization CKC）,术后6、12、18、24个月分别行HR-HPV检测进行随访.对治疗后HR-HPV的清除趋势进行回顾性分析.结果：1.CIN病变治疗后未复发及残留者术后6、12、18、24个月HR-HPV清除率分别为78.20％、89.74％、96.10％、98.72％.CIN Ⅰ、CINⅡ、CINⅢ各组锥切术后HR-HPV清除率之间无统计学差异（P＞0.873）.结论：1.CIN治疗后6个月HR-HPV可大部分消退,术后2年基本完全消退.CIN治疗后HR-HPV清除率与病变级别之间无显著相关性.

Clearance Tendency of High Risk HPV After Treatment of Cervical Intraepithelial Neoplasia

Objective： To approach the clearance tendency of high risk HPV after treatment of cervical intraep, ithelial neoplasm （CIN） Methods： A retrospective study was conducted on 90 women who underwent LEEP or CKC for cervical intraepithelial neoplasm in Xinjiang General Hospital from august 2008 to December 2009.For all patient with HR-HPV positive hybrid capture Ⅱ method was used to detect viral load of HR-HPV respectively 6,12,18,24 months after treatment. Results：l. Among those who were high-risk HPV infected before eonization of cervix and there was no residua or recurrence after treatment, the clearance rate of high-risk HPV in CINwas78.20% ,89.74%, 96.10%,98.72% after treatment 6, 12, 18 and 24months, respectively. There was no significant difference in persis- tent masculine of HR-HPV among biopsy histology CIN Ⅰ,CIN Ⅱ and CIN Ⅲ .Conclusion： 1.HR-HPV could subtotal cleared 6 months after conization, and could foundational completely cleared in 2years,