| 不同程度减压低氧对心肌肌浆网钙摄取和Ca~（2＋）－ATP酶活性的影响 |
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| 引用本文： | 孙希武,叶益新,邓希贤. 不同程度减压低氧对心肌肌浆网钙摄取和Ca~（2＋）－ATP酶活性的影响[J]. 中国医学科学院学报, 1996, 0(1) |
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| 作者姓名： | 孙希武 叶益新 邓希贤 |
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| 作者单位： | 中国医学科学院，中国协和医科大学基础医学研究所 |
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| 摘 要： | 将实验大鼠分别置于模拟５０００和８０００ｍ海拔高度的低压仓内７ｄ，观察两种减压低氧对大鼠左心功能及左心室肌肌浆网（ＳＲ）钙摄取及Ｃａ~（２＋）－ＡＴＰ酶活性的影响。结果表明，５０００ｍ低氧大鼠左心功能抑制程度明显轻于８０００ｍ低氧，ＳＲＣａ~（２＋）－ＡＴＰ酶活性及~（４５）Ｃａ~（２＋）摄取降低程度也明显低于８０００ｍ低氧，ＡＴＰ酶和钙摄取的变化基本一致。从而推论，心肌ＳＲＣａ~（２＋）－ＡＴＰ酶活性及~（４５）Ｃａ~（２＋）摄取的改变可能是心功能变化的病理生理基础之一。
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| 关 键 词： | 低氧，心室功能，肌浆网，Ca~（2＋）－ATP酶，钙摄取 |
Changes in Calcium Uptake and Ca2 -ATPase Activity of Cardiac Sarcoplasmic Reticulum in Rat Associated with Hypoxia of Various Degrees |
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| Sun Xiwu, Ye Yixin, Deng Xixian. Changes in Calcium Uptake and Ca2 -ATPase Activity of Cardiac Sarcoplasmic Reticulum in Rat Associated with Hypoxia of Various Degrees[J]. Acta Academiae Medicinae Sinicae, 1996, 0(1) |
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| Authors: | Sun Xiwu Ye Yixin Deng Xixian |
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| Abstract: | Two groups of Wistar rats were exposed to hypoxia at 5000 to 8000m high above the sealevel in a hypobaric chamber for 7 days. The effects of hypoxia on left cardiac function,sar-coplasmic reticulum(SR)Ca2 ATPase activity and SR calcium uptake were observed.The resuIts indicated that the left ventricular function exposed to hypoxia at 5000m was much higher than that at 8000m.Calcium uptakeand Ca2 ATPase activity of the exposed groupsdecreased significantly compared with those of the control group,but they were much higher in the exposed group at 5000m than at 8000m. These results suggest that the changes in cal-cium uptake and Ca2 ATPase activity of SR may be one of the important biochemical indica-tors for cardiac function alterations associated with hypoxia. |
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| Keywords: | hypoxia left cardiac function cardiac sarcoplasmic reticulum Ca2 ATPase calciuni up-take |
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