微量白蛋白尿与老年患者血管性认知功能障碍、颈动脉硬化的关系

目的 探讨微量白蛋白尿与血管性认知功能障碍（vascular congnitive impairment,VCI）、颈动脉硬化的关系,为早期发现和预防血管性认知功能障碍提供临床参考.方法 采集98例缺血性脑卒中老年患者一般资料,依据卒中后3个月的认知评定结果及相应的诊断标准分为VCI组和认知正常组（对照组）,所有病例均进行颈动脉超声检测和神经心理检查,采用免疫透射比浊法测尿微量白蛋白（MAU）,对两组数据进行比较分析.结果 VCI组患者年龄较对照组偏高,受教育年限较对照组偏低,差异有统计学意义（P＜0.05）;VCI组患者MMSE评分较对照组明显降低,差异有统计学意义（P＜0.01）.VCI组患者尿MAU水平较对照组明显增高,差异有统计学意义（P＜0.01）;根据IMT程度将VCI患者分为两组,IMT＞ 1.0 mm组与IMT＜ 1.0 mm组相比MAU水平明显增高,差异有统计学意义（P＜0.05）.结论 MAU水平升高是VCI患者认知功能损害、颈动脉粥样硬化的危险因素.

The relationship between micro-albuminuria,elderly vascular cognitive impairment and carotid atherosclerosis

Objective Objective To investigate the relationship between MAU, vascular cognitive impairment（VCI） and carotid atherosclerosis, to provide clinical reference for early discovery and prevention of vascular cognitive impairment. Methods General information was collected from 98 cases of senile patients with cerebral apoplexy, the patients were divided into VCI group and normal cognition group （control group） according to cognitive assessment results 3 months after stroke and the corresponding diagnostic criteria. Neuropsyehology examination and ultrasonic measurement on carotid artery were performed for all the patients,immune turbidimetric method was used to determine albumin in urine, and then compared the datas. Results Compared with control group, years of education and MMSE score in VCI group is lower but average age and the level of MAU were higher,the differences were statistically significant （P 〈 0. 05,0.01 ） ;Patients in VCI group were divided into 2 groups according to the IMT level, MAU level of IMT 〉 1.0 mm group was higher than IMT 〈 1.0 mm group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusions The increasing of MAU is a risk factor of cognitive impairment and carotid atherosclerosis of VCI patients.