综合护理干预胸腺蛋白口服液联合冰敷治疗60例鼻咽癌急性放射性口腔黏膜反应的效果观察

目的探讨综合护理干预胸腺蛋白口服液联合冰敷治疗鼻咽癌急性放射性口腔黏膜反应的临床效果。方法抽取我院2011年1月至2013年10月份收治的60例经胸腺蛋白口服液联合冰敷治疗的鼻咽癌急性放射性口腔黏膜反应患者作为研究对象,并随机分为对照组和观察组,每组30例。对照组采用常规护理,观察组采用综合护理干预,包括环境干预、心理干预、口腔护理、生活干预以及出院指导。比较和分析两组的临床治疗效果。结果经护理干预后,发现观察组30例患者的口腔黏膜反应均得到有效控制,与对照组的比较,差异有统计学意义（P〈0.05）。并且在恢复时间方面,观察组为（24.0±3.6）d,明显优于对照组的（32.3±4.7）d,比较差异有统计学意义（P〈0.05）。结论给予胸腺蛋白口服液联合冰敷治疗的鼻咽癌急性放射性口腔黏膜反应患者综合护理干预,能够有效缓解患者的口腔黏膜反应,提高临床治疗效果,具有较高的临床应用价值,值得进一步推广。

The effectiveness of comprehensive nursing intervention in treating acute radioactive oral mucosa reaction of nasopharyngeal carcinoma with thymus protein oral solution and ice compress

Objective To assess the effectiveness of comprehensive nursing intervention in treating acute radioactive oral mucosa reaction of nasopharyngeal carcinoma with thymus protein oral solution and ice compress. Methods Retrospectively analysis the datas of 60 cases of nasopharyngeal carcinoma patients, those who got therapy in our hospital during January 2011 and October 2013, they were randomly divided into control group and observation group, and all of them received the treatment of thymus protein oral solution and ice compress. Patients in observation group were given comprehensive nursing intervention （including environmental intervention, psychological intervention, oral care, life intervention and discharge guidance）, but patients in control group were given conventional nursing. The degree of acute radioactive oral mucosa reaction was assessed and compared clinical therapeutic effect in two groups. Results Acute radioactive oral mucosa reaction was reduced in the observation group, compared with the control group, the difference between the two groups was statistically significant （P 〈 0. 05 ）. The recovery period of oral mucosa reaction in observation group （24.0 ± 3.6 days） was significantly shorter than that in the control group （ 32.3 ± 4.7 days） （ P 〈 0. 05 ）. Conclusions The comprehensive nursing intervention can significantly relieve the reaction of acute radiation - induced oral mucosa, could improve clinical outcomes in patients with nasopharyngeal carcinoma, it has high clinical value and worthyof further promotion.