我院抗菌药物不良反应／事件报告分析

目的通过对我院428例抗菌药品不良反应／事件（ADR／ADE）报告相关因素分析，了解抗菌药物ADR／ADE发生特点及规律，为临床安全、有效、合理用药提供参考。方法对我医院2009年1月113至2013年12月3113收集到的428例抗菌药物ADR／ADE报告数据进行回顾性统计分析。结果428例抗菌药品ADR／ADE报告中，女性多于男性；0—14岁的儿童61例（占14．26％）；50～83岁的患者264例（占61．68％）；头孢菌素类居首位239例（占55．85％）；给药途径以静脉点滴所占比例最大385例（占89．96％）；抗菌药物ADR／ADE主要临床表现为皮肤及其附件、消化系统、全身性损害等。结论加强抗菌药物ADR／ADE监测工作，减少或者避免ADR／ADE的发生，确保临床安全、有效、合理用药。

Analysis on adverse drug reaction/event reports of antibacterial agents

Objective To learn the adverse drug reactions/events （ADR/ADE） occurred in the characteristics and rules for clinical safe, effective and rational use of available information by analysis of 428 antibacterial agents ADR/ADE Reports. Methods 428 antibacterial agents ADR/ADE Reports were statistical analyzed from Jan 1, 2009 to Dec 31, 2013 in our hospital. Results 428 cases of antibacterial agents ADR/ ADE, females was slightly more than males; patients between 50 to 83 years old age were accounted for the majority （264cases,61.68%） ; the cases that caused by cephalosporins were accounted for the most （239case, 55.85% ）, 385 case that administered intravenously were accounted for the majority （ 89.96% ） ; antibacterial agents ADR/ADE main clinical manifestations of anaphylactic shock, respiratory, systemic and central nervous system damage. Conclusions Strengthening antibacterial agents ADR/ADE monitoring, to decrease the occurrence of serious ADR/ADE and ensure clinical safety, effective, rational use of drug.