药源性出血1139例分析

目的:探讨药源性出血的一般规律及特点。方法:对1994年1月～2004年12月国内医药学期刊报道的药源性出血1139例进行统计、分析。结果:诱发出血的药物种类以抗微生物药、中枢神经系统药及血液系统药为主;诱发出血的给药方式以口服给药为多,占63.92%;出血部位主要为消化道、肠道;出血时间在用药后2min～1mo;全身给药所致出血多为正常用法、用量下,而局部用药则有错误用药、用药不当等原因。结论:临床医师交代患者用药应详细,以避免错误或者不当用药。

Analysis of 1 139 Case of Drug- induced Hemorrhage

OBJECTIVE:To discuss the general regularity and characteristics of drug-induced hemorrhage.METHEDS:1139cases of drug-induced hemorrhage reported in internal medical journals published from Jan.1995to Dec.2004were collected and analyzed.RESULTS:The drugs that induced hemorrhage were chiefly antimicrobial drugs,central nervous system drugs and hematopoietic system drugs;oral drugs were the chief means that lead to hemorrhage which amounted to63.92%of the total hemorrhage cases;the bleeding parts were mainly alimentary tract and intestinal tract;the bleeding time usually occurred within2min～1mo after medication.Systematic administration-induced hemorrhage usually occurred under the normal administration and dosage;however,wrong use of drugs,irrational drug uses etc.were accountable for the hemˉorrhage in local application.CONCLUSION:Clinicians should give detailed guidance to patients on the drug use so as to avoid wrong or irrational drug use.