Differences in water diffusion and lactate production in two different types of postinfectious encephalopathy |
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Authors: | Harada M Hisaoka S Mori K Yoneda K Noda S Nishitani H |
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Institution: | Department of Radiology, School of Medicine, University of Tokushima, Tokushima 770-8503, Japan. masafumi@clin.med.tokushima-u.ac.jp |
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Abstract: | We compared two different types of postinfectious encephalopathy using magnetic resonance imaging (MRI), including diffusion-weighted images and MR spectroscopy. Acute disseminated encephalomyelitis (ADEM) and acute necrotizing encephalopathy (ANE) showed different distribution of abnormal intensity areas and different diffusion of water measured by diffusion-weighted imaging (DWI). Proton MR spectroscopy (MRS) showed lactate production in both cases, which returned to a normal range; the rate of increased lactate production was much lower in the ANE case. Water diffusion showed a difference in pathophysiological background between the two encephalopathies, but the lactate elevation observed by proton MRS did not correlate with clinical severity. |
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