The two-in-one model: a new variation of the arteriovenous malformation model in swine |
| |
| Authors: | J Klisch F Requejo L Yin B Eissner M Schumacher |
| |
| Institution: | (1) Section of Neuroradiology, Department of Neurosurgery, University of Freiburg, Breisacher Str. 64, 79 106 Freiburg, Germany e-mail: klisch @ nz 11.ukl.uni-freiburg.de Tel.: + 49-7 61-2 70 51 80 Fax: + 49-7 61-2 70 51 95, DE;(2) Department of Neurosurgery, Hospital Municipal Central de San Isidro, San Isidro, Buenos Aires, Argentina, AR;(3) Department of Surgery, Surgical Research, University of Freiburg, Breisacher Str. 64, 79 106 Freiburg, Germany, DE |
| |
| Abstract: | We report a new variation of the well-established experimental arteriovenous malformation (AVM) model in swine. To provide
high flow through the rete mirabile (nidus, RM) and thereby to reduce the rate of spontaneous thrombosis of the AVM, we performed
an end-to-end anastomosis of the left common carotid artery (CCA) and the external jugular vein (EJV) microsurgically in three
micropigs. After 1 and 4 months the animals underwent angiograms of the CCA and vertebral artery (VA). In all cases the diversion
of the blood through the RM was patent, up to the 4 months follow-up. We observed an arteriovenous fistula (arteriovenous
pseudomalformation, pAVF) between the VA and the EJV in each case at both 1 and 4 months. This modification of the well-known
AVM model in the micropig could be used to monitor long-term changes after embolisation, avoiding the naturally high rate
of spontaneous thrombosis. This two-in-one model is thus well suited for preclinical testing of embolic materials.
Received: 2 December 1999 Accepted: 31 August 2000 |
| |
| Keywords: | Arteriovenous malformation experimental Pigs Embolisation |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
