| 登革Ⅱ型病毒对淋巴细胞和骨髓细胞SCE率影响的实验研究 |
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| 引用本文： | 何政贤,邹小兵,汪李虎,王清文,黄略峰.登革Ⅱ型病毒对淋巴细胞和骨髓细胞SCE率影响的实验研究[J].中华医学遗传学杂志,1994(4). |
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| 作者姓名： | 何政贤 邹小兵 汪李虎 王清文 黄略峰 |
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| 作者单位： | 中山医科大学第三附属医院儿科遗传实验室，广东省妇幼保健院 |
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| 摘 要： | 报道３０例离体培养的人体外周血淋巴细胞及２０例离体培养的正常人骨髓细胞加入登革Ⅱ型病毒前后的ＳＣＥ率改变，结果表明：登革Ⅱ型病毒可以提高外周血淋巴细胞及骨髓细胞的ＳＣＥ率，说明该病毒对人体这两类细胞的染色体均具有损伤作用。实验还观察到不同个体的淋巴细胞及骨髓细胞在加入登革Ⅱ型病毒后，其ＳＣＥ率的升高有个体差异，说明了染色体或ＤＮＡ损伤程度不等。
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| 关 键 词： | 登革病毒，淋巴细胞，骨髓细胞，姐妹染色单体互换 |
EXPERIMENTAL STUDY OF EFFECTS OF DENGUE VIRUS 2 ON SCE FREQUENCY OF THE LYMPHOCYTES AND BONE MARROW CELL IN VITRO. |
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| He Zhengxian,Zou Xiaobin,Wang Lihu,et al..EXPERIMENTAL STUDY OF EFFECTS OF DENGUE VIRUS 2 ON SCE FREQUENCY OF THE LYMPHOCYTES AND BONE MARROW CELL IN VITRO.[J].Chinese Journal of Medical Genetics,1994(4). |
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| Authors: | He Zhengxian Zou Xiaobin Wang Lihu |
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| Institution: | He Zhengxian,Zou Xiaobin,Wang Lihu,et al.Department of Pediatrics,The Third Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510630) |
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| Abstract: | Thirty samples of peripheral blood lymphocytes and 20 samples of normal human bone marrow cell were used; each was added Dengue virus 2 in vitro cultured.The results showed:SCE frequency was increased,which suggested that Dengue virus 2 damage the chromosome of its host cell.In addition,it was found that SCE frequencies were statistically different among various individuals after the treatment of Dengue virus 2 in the study.This finding may sugggest that genetic susceptibility exist in the development of Dengue virus infection. |
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| Keywords: | Dengue virus Lymphocyte Bone marrow cell Sister chromatid exchange |
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