肝母细胞瘤患儿及其母亲孕期特点回顾性分析

目的 探讨肝母细胞瘤发生的危险因素,包括婴儿出生以及孕产妇分娩相关的特征.方法 采用病例-对照研究设计,收集肝母细胞瘤患儿及其母亲的病历资料,用Logistic回归模型对婴儿特征指标、母亲怀孕与分娩有关指标进行多因素统计检验. 结果发生肝母细胞瘤风险中低出生体质量儿的比值比为26.0(95%可信区间为14.0～65.7).母亲≤20岁和≥30岁的比值比分别为1.5(95%可信区间为0.6～4.6)和2.6(95%可信区间为1.0～6.7).超重和肥胖母亲的比值比为3.2(95%可信区间为1.0～6.7).孕妇吸烟的比值比为2.9(95%可信区间为1.1～4.2),对>2岁及H{生体质量正常儿童影响较大. 结论肝母细胞瘤的发生与患儿出生体质量及孕妇超重、吸烟等因素有关,应重视围产期卫生保健.

Retrospective analysis of maternal and infant birth features of hepatoblastoma patients

Objective To explore the risk factors for hepatoblastoma. Methods A case-cohort study using Logistic regression multiple variables analysis of medical record data sets was conducted to examine infant and perinatal risk factors for hepatoblastoma. Results Birth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (odds risk, OR = 26.0, 95% confidence interval, CI: 14.0-65.7). After adjustment of birth weight, a moderately increased risk of hepatoblastoma was found for older maternal age (> 35 years vs. 20-34 years: OR = 2.6, 95% CI: 0.9-5.9), maternal smoking (OR = 2.9, 95% CI: 1.1-4.2) and higher maternal pregnancy body mass index (OR = 3.2, 95% CI: 1.0-6.7). Conclusions Very low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.