酸浆水提物对高脂膳食大鼠肝脏及血脂水平影响

目的 探讨酸浆水提物对实验性高脂血症大鼠血脂水平的影响。方法 40只Wistar大鼠随机分为正常组,模型组和酸浆低、中、高剂量组。除正常组外均喂高脂饲料,酸浆低、中、高剂量组每天以1.5、7和37.5 g/kg酸浆水提物灌胃,连续30 d,测定大鼠血清总胆固醇(TC)、血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算肝脏指数。结果 酸浆低、中、高剂量组TG分别为(0.42±0.08)、(0.44±0.11)、(0.39±0.09)mmol/L,均低于模型组(0.56±0.16)mmol/L(P<0.05),而TC、LDL-C、HDL-C各组与模型组则无明显差异;酸浆各剂量组肝脏指数均低于模型组(P<0.05)。结论 酸浆水提物具有一定的降血脂作用。

Effects of Physalis alkekengi water extraction on liver and blood lipid levels of rats with high fat diet

Objective To study effects of Physalis alkekengi water extraction on blood lipid levels of experimental rats with hyperlipidemia.Methods Forty male Wistar rats were randomly divided into five groups:a normal group,a hyperlipidemia model group and low-,medium-,and high-dose Physalis alkekengi treatment groups.The rats in the four groups other than the normal group were fed with high fat feedstuff;the rats in the three treatment groups were gavaged with Physalis alkekengi water extraction at the doses of 1.5,7.5,and 37.5g/kg once a day continuously for 30 days.Then serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low density lipo-protein cholesterol(LDL-C) were detected and liver indexes were determined for all the rats.Results The TG contents of the rats in the three of Physalis alkekengi treatment groups were 0.42±0.08,0.44±0.11,and 0.39±0.09 mmol/L,respectively and were all lower than that in the model group(0.56±0.16 mmol/L)(all P<0.05),whereas the contents of TC,LDL-C,and HDL-C in the treatment groups were not significantly different compared to those in the model group(all P<0.05).The average liver indexes of the three Physalis alkekengi treatment groups were lower than that of the model group(all P<0.05).Conclusion Physalis alkekengi water extraction could reduce blood lipid at a certain extent in rats.