Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp |
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| Authors: | Lang Gerhard Blunt John W Cummings Nicholas J Cole Anthony L J Munro Murray H G |
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| Affiliation: | Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. |
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| Abstract: | The entomopathogenic fungus Hirsutella sp., isolated from an infected spider, was found to produce the new cyclotetrapeptide hirsutide (1), cyclo-(L-NMe-Phe-L-Phe-L-NMe-Phe-L-Val), along with the known cytochalasin Q (2), using a cytotoxicity-guided isolation procedure. The structure of 1 was elucidated using one- and two-dimensional NMR experiments, mass spectrometry, and Marfey's method for analyzing the configuration of the amino acids. |
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