| 雄黄中砷的不同形态及其毒性研究进展 |
| |
| 引用本文： | 高双荣,梁爱华,易艳,刘婷,曹春雨,王海林,李春英,郝然,回连强.雄黄中砷的不同形态及其毒性研究进展[J].中国实验方剂学杂志,2011,17(24):243-247. |
| |
| 作者姓名： | 高双荣 梁爱华 易艳 刘婷 曹春雨 王海林 李春英 郝然 回连强 |
| |
| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
| |
| 基金项目： | 国家自然科学基金项目(81001692);中国中医科学院自主选题项目(ZZ03046); 国家科技重大专项(2009ZX09301005); 国家"十一五"科技支撑计划项目(2006BAI55B02-03) |
| |
| 摘 要： | 对雄黄中不同形态砷的毒性及其毒性机制进行文献整理和分析。查阅了国内外有关文献28篇,进行归纳整理并分析汇总。首先介绍了其对肝、肾、膀胱、神经、皮肤、胎儿发育等的毒性损伤情况及损伤机制,砷在生物体内以无机砷和有机砷等不同形态存在,依形态不同毒性有较大差异:三价砷(AsⅢ)可引起肝细胞的凋亡和灶状坏死,五价砷(AsⅤ),五价甲基砷酸(MMAⅤ),五价二甲基砷酸(DMAⅤ)可引起肝细胞肿胀和灶状炎症。DMAⅤ的毒性较MMAⅤ大,若长期接触DMAⅤ和MMAⅤ可引起动物膀胱和皮肤组织肿瘤。MMAⅤ和DMAⅤ对调节神经丝蛋白基因的毒性较亚砷酸盐(iAsⅢ)和砷酸盐(iAsⅤ)强,能明显改变细胞骨架基因的表达水平。此外,iAsⅢ和MMAⅢ对人造血干细胞也能产生明显的毒性。这些总结将为系统探究雄黄不同形态砷与毒性的相关性提供基础。
|
| 关 键 词： | 砷 化学形态 毒性 |
| 收稿时间： | 8/8/2011 12:00:00 AM |
Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity |
| |
| GAO Shuang-rong,LIANG Ai-hu,YI Yan,LIU Ting,CAO Chun-yu,WANG Hai-lin,LI Chun-ying,HAO Ran and HUI Lian-qiang.Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity[J].China Journal of Experimental Traditional Medical Formulae,2011,17(24):243-247. |
| |
| Authors: | GAO Shuang-rong LIANG Ai-hu YI Yan LIU Ting CAO Chun-yu WANG Hai-lin LI Chun-ying HAO Ran and HUI Lian-qiang |
| |
| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
| |
| Abstract: | |
| |
| Keywords: | arsenic chemical form toxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 |
|
