VEGF-independent angiogenic pathways induced by PDGF-C |
| |
Authors: | Xuri Li Anil Kumar Fan Zhang Chunsik Lee Yang Li Zhongshu Tang Pachiappan Arjunan |
| |
Affiliation: | National Eye Institute, NIH, Rockville, MD, 20852, USA |
| |
Abstract: | VEGF is believed to be a master regulator in both developmental and pathological angiogenesis. The role of PDGF-C in angiogenesis, however, is only at the beginning of being revealed. We and others have shown that PDGF-C is a critical player in pathological angiogenesis because of its pleiotropic effects on multiple cellular targets. The angiogenic pathways induced by PDGF-C are, to a large extent, VEGF-independent. These pathways may include, but not limited to, the direct effect of PDGF-C on vascular cells, the effect of PDGF-C on tissue stroma fibroblasts, and its effect on macrophages. Taken together, the pleiotropic, versatile and VEGF-independent angiogenic nature of PDGF-C has placed it among the most important target genes for antiangiogenic therapy. |
| |
Keywords: | PDGF-C angiogenesis VEGF choroidal neovascularization |
|
|