Detection of rare reassortant G5P[6] rotavirus,Bulgaria |
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| Authors: | Zornitsa Mladenova Hajnalka Papp György Lengyel Péter Kisfali Andrej Steyer Adela F. Steyer Mathew D. Esona Miren Iturriza-Gómara Krisztián Bányai |
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| Affiliation: | 1. National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria;2. Institute for Veterinary Medical Research, Budapest, Hungary;3. Dr. György Radó Military Medical Centre, Budapest, Hungary;4. University of Pécs, Pécs, Hungary;5. University of Ljubljana, Ljubljana, Slovenia;6. Centers for Disease Control and Prevention, Atlanta, GA, USA;7. Health Protection Agency, London, United Kingdom;1. Wuhan Centers for Disease Prevention and Control, Wuhan, Hubei Province, China;2. Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan;1. United States Naval Medical Research Unit No. 3, Cairo, Egypt;2. College of Veterinary Medicine, University of Baghdad, Iraq;3. Central Public Health Laboratory, Ministry of Health, Baghdad, Iraq;4. Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium;5. Eastern Mediterranean Regional Office, World Health Organization, Cairo, Egypt;1. Departamento de Biología Molecular y Genética, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay;2. The J. Craig Venter Institute, Rockville, MD, USA;1. Canadian Food Inspection Agency, St-Hyacinthe Laboratory, 3400 Blvd Casavant West, St-Hyacinthe, Quebec, Canada J2S 8E3;2. Department of Veterinary Public Health, Faculty of Veterinary Medicine of Bari, 70010 Valenzano, Bari, Italy;1. Division of Virology, National Institute of Cholera and Enteric Diseases, P-33 C.I.T. Road Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India;2. Department of Hygeine, Sapporo Medical University, S-1 W-17, Chuo-ku, Sapporo 060-8556, Japan;1. Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan;2. Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;3. Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;4. Animal House Unit, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand |
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| Abstract: | During the ongoing rotavirus strain surveillance program conducted in Bulgaria, an unusual human rotavirus A (RVA) strain, RVA/Human/BG/BG620/2008/G5P[6], was identified among 2200 genotyped Bulgarian RVAs. This strain showed the following genomic configuration: G5–P[6]–I1–R1–C1–M1–A8–N1–T1–E1–H1. Phylogenetic analysis of the genes encoding the neutralization proteins and backbone genes identified a probable mixture of RVA genes of human and porcine origin. The VP1, VP6 and NSP2 genes were more closely related to typical human rotavirus strains. The remaining eight genes were either closely related to typical porcine and unusual human–porcine reassortant rotavirus strains or were equally distant from reference human and porcine strains. This study is the first to report an unusual rotavirus isolate with G5P[6] genotype in Europe which has most likely emerged from zoonotic transmission. The absence of porcine rotavirus sequence data from this area did not permit to assess if the suspected ancestral zoonotic porcine strain already had human rotavirus genes in its genome when transmitted from pig to human, or, the transmission was coupled or followed by gene reassortment event(s). Because our strain shared no neutralization antigens with rotavirus vaccines used for routine immunization in children, attention is needed to monitor if this G–P combination will be able to emerge in human populations. A better understanding of the ecology of rotavirus zoonoses requires simultaneous monitoring of rotavirus strains in humans and animals. |
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