Full genomic analysis of rabbit rotavirus G3P[14] strain N5 in China: Identification of a novel VP6 genotype |
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| Authors: | Dongchun Guo Jiasen Liu Yan Lu Yan Sun Dongwei Yuan Qian Jiang Huan Lin Changwen Li Changde Si Liandong Qu |
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| Institution: | 1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China;2. College of Animal Science and Veterinary Medicine, Heilongjiang August First Agricultural University, Daqing 163319, China;1. Wuhan Centers for Disease Prevention and Control, Wuhan, Hubei Province, China;2. Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan;1. South African Medical Research Council/Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria, South Africa;2. African Rotavirus Surveillance Network, Immunization, Vaccines and Development Cluster, WHO African Regional Office, Brazzaville, Congo;3. World Health Organization, Inter-Country Support Team Office, Harare, Zimbabwe;4. Enteric and Diarrheal Diseases, Global Health Program, Bill and Melinda Gates Foundation, Seattle, USA;1. Division of Virology, National Institute of Cholera and Enteric Diseases, P-33 C.I.T. Road Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India;2. Department of Hygeine, Sapporo Medical University, S-1 W-17, Chuo-ku, Sapporo 060-8556, Japan;1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas;2. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas;1. Instituto de Microbiologia Paulo de Góes; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21.947-902, Brazil;2. Laboratorio de Microbiologia y Parasitologia, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, (FMV/UNMSM), Lima, Apartado 03-5137, Peru;3. Instituto Veterinario de Investigaciones Tropicales y de Altura (IVITA), Cuzco, Peru;1. Enteric Virus Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia;2. Department of Microbiology, La Trobe University, Melbourne, Victoria, Australia;3. School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia;4. SAEFVIC, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia;5. Department of Infectious Diseases, Monash Children’s Hospital, Melbourne, Victoria, Australia;6. Department of Paediatrics, Monash University, Melbourne, Victoria, Australia;7. Department of General Medicine, Royal Children’s Hospital, Melbourne, Victoria, Australia;8. Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia |
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| Abstract: | Group A rotaviruses (RVAs) are major pathogens associated with acute gastroenteritis in young children and in a wide variety of domestic animals. The full-length genome of a rabbit RVA strain, RVA/Rabbit-tc/CHN/N5/1992/G3P14], showed a G3-P14]-I17-R3-C3-M3-A9-N1-T1-E3-H2 genomic configuration. A novel VP6 genotype, I17, was confirmed by the Rotavirus Classification Working Group. Phylogenetic analyses revealed that strain N5 possessed VP1–3, VP7, NSP1–2 and NSP4 genes closely related to those of the simian strain TUCH, NSP3 and NSP5 genes closely related to the human strains Wa and 69M, and a VP4 gene closely related to the rabbit strain 30/96 and sheep strain OVR762. The RRV and TUCH shared their ancestry with canine/feline RVAs and showed a close relationship to the human T152/feline-like RVAs. Comparison with the genotypes of the simian strains TUCH and RRV, canine strains A79-10, CU-1, K9, feline strains Cat2 and Cat97, and human strains T152 and 69M showed that RVA/Rabbit-tc/CHN/N5/1992/G3P14] was possibly of feline/canine origin, or was a multiple reassortment involving canine, feline and human rotaviruses. The sequencing and phylogenetic analyses of rotavirus genomes is critical to the elucidation of the patterns of virus evolution. |
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