In vivo real-time confocal microscopy for target-specific delivery of hyaluronic acid-quantum dot conjugates |
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| Authors: | Ki Su Kim Seonghoon Kim Songeun Beack Jeong-A Yang Seok Hyun Yun Sei Kwang Hahn |
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| Affiliation: | 1. Department of Materials Science and Engineering, Pohang University of Science and Technology Pohang, Republic of Korea;2. Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejon, Republic of Korea;3. Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Cambridge, Massachusetts, USA |
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| Abstract: | Hyaluronic acid (HA), which is a biocompatible, biodegradable, and linear polysaccharide in the body, has been widely used for various biomedical applications. In this work, real-time bioimaging for target-specific delivery of HA derivatives was carried out using quantum dots (QDs). In vitro confocal microscopy of HA-QD conjugates confirmed the intracellular delivery of HA derivatives to B16F1 cells with HA receptors by HA-receptor-mediated endocytosis. Furthermore in vivo real-time confocal microscopy of HA-QD conjugates successfully visualized the target specific delivery and accumulation of HA-QD conjugates from the fluorescence-labeled blood vessels to the liver tissues. The authors could confirm the feasibility of HA derivatives as a target-specific intracellular drug-delivery carrier for the treatment of liver diseases and the in vivo real-time confocal microscopy as a new bioimaging tool for various drug-delivery applications.From the Clinical EditorThis study demonstrates the possibility of labeling hyaluronic acid with quantum dots for visualization and for targeted intracellular drug delivery in liver disease models. |
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