Pertussis in practice in 2007] |
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| Authors: | E Grimprel |
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| Institution: | 1. National Pertussis Reference Laboratory, Service Immunology, Scientific Institute of Public Health (WIV-ISP), 1180 Brussels, Belgium;2. Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, University of Antwerp, 2610 Wilrijk, Belgium;1. Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands;2. Utrecht University, Faculty of Veterinary Medicine, Department Animals in Science and Society, Utrecht, The Netherlands;3. Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, The Netherlands;4. Utrecht University, Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht, The Netherlands;1. Laboratorio VacSal, Instituto de Biotecnología y Biología Molecular (IBBM), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT-CONICET La Plata, Calles 50 y 115, 1900 La Plata, Argentina;2. Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT-CONICET La Plata, 47 y 115, 1900 La Plata, Argentina;1. Department of Paediatrics and Child Health, University of Cape Town, 7701 Cape Town, South Africa;2. National Institute for Communicable Diseases and University of the Witwatersrand, 2131 Johannesburg, South Africa;3. Department of Paediatrics & Child Health, Makerere University College of Health Sciences, 7072 Kampala, Uganda;4. Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;5. Max Super Speciality Hospital, Shalimar Bagh, New Delhi 110 088, India;6. Flinders University and Flinders Medical Centre, Bedford Park, 5042 Adelaide, Australia;7. Labor:Medizin Krefeld MVZ GmbH, 47805 Krefeld, Germany;8. Department of Pathology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, 7701 Cape Town, South Africa;1. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;2. Department of Peadiatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Center, Utrecht, The Netherlands |
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| Abstract: | Universal vaccination of infants against pertussis has transformed the epidemiology of the disease. Pertussis has however become frequent, although not often diagnosed, in adolescents and adults and thus contributes to permanent transmission of Bordetella pertussis in France and contamination of young infants at risk of severe disease. Control of transmission of pertussis in France necessitates reinforcement of vaccination with late boosters in adolescents and adults and, in addition, education of physicians to recognize and treat early cases of pertussis, especially in adolescents and adults with a persistent or chronic cough, and to take appropriate prophylactic measures (antibiotics and recall vaccination) of those in contact with confirmed cases. Effective treatment does little to reduce symptoms but it does reduce transmission. Macrolides are the recommended treatment for pertussis. |
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