| 人血丙种球蛋白制备的新工艺 |
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| 引用本文： | 刘鹏输,何承举.人血丙种球蛋白制备的新工艺[J].中国生化药物杂志,1995,16(2):72-75. |
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| 作者姓名： | 刘鹏输 何承举 |
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| 作者单位： | 广西血液中心!柳州545005 |
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| 摘 要： | 本文报道了利凡诺-低温乙醇-DEAE离子交换层析结合法制备人血丙种球蛋白的新工艺,按此工艺,IgG收率约0.5％（g/ml）,纯度>99％,制剂各项指标均符合规程要求。以VSV为病毒模型,制备过程至少可失活或排除10~(11)ID_(50)/ml病毒,工艺对灭活脂质壳病毒是有效的。
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| 关 键 词： | 人血丙种球蛋白 病毒灭活 VSV |
A New Production Technology of Human Immunoglobulin G |
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| Liu Penghan,He Chengju,Pang Yuefei,Li Xin,Lu Ping Gisangxi Kegkm Blood Center.A New Production Technology of Human Immunoglobulin G[J].Chinese Journal of Biochemical Pharmaceutics,1995,16(2):72-75. |
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| Authors: | Liu Penghan He Chengju Pang Yuefei Li Xin Lu Ping Gisangxi Kegkm Blood Center |
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| Institution: | Liuzhou 545005 |
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| Abstract: | A new human Immunoglobulin G production technology by Rivanol-cold ethaonl-DEAE ion-exchange chromatography was reported in this paper. According to this technological process, IgG recovery was 0. 5% (g/ml) or so, and purity> 99%. All quality index of IgG preparation could meet the clinical requirement. The technological process could inactived or removed 1013lD50/ml VSV at least. |
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| Keywords: | Human Immunoglobulin G Virus inactivation VSV |
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