| 山茱萸总苷对大鼠实验性变态反应性脑脊髓炎的初步观察 |
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| 引用本文： | 李勇,宋兴伟,代允义,管璇,王小同,张长国.山茱萸总苷对大鼠实验性变态反应性脑脊髓炎的初步观察[J].中国临床神经科学,2009,17(2):118-122. |
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| 作者姓名： | 李勇 宋兴伟 代允义 管璇 王小同 张长国 |
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| 作者单位： | 1. 温州医学院第二附属医院神经内科,325000
2. 温州医学院第二附属医院儿童ICU,325000 |
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| 摘 要： | 目的：观察山茱萸总苷（TGCO）对大鼠实验性变态反应性脑脊髓炎（EAE）的影响。方法：Wistar大鼠24只随机分为3组：正常对照组、EAE组和TGCO组。采用动物行为学、常规苏木精-伊红染色和LFB髓鞘染色观察大鼠的发病情况与中枢神经系统（CNS）的病理变化。结果：EAE组7／8只大鼠出现典型的EAE行为学改变、CNS炎性细胞浸润和髓鞘脱失。TGCO组有3，8只大鼠出现EAE行为学改变，评分最高为29，潜伏期延长，CNS内炎性细胞浸润和髓鞘脱失明显减轻。对照组未见动物行为学和CNS病理学改变。结论：TGCO能减轻EAE大鼠的临床症状、延长潜伏期和降低发病率。
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| 关 键 词： | 多发性硬化 脑脊髓炎 山茱萸总苷 实验性变态反应性脑脊髓炎 |
Primarily Research of Total Glycosides from Cornus Officinalis on Experimental Allergic Encephalomyelitis in Rats |
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| LI Yong,SONG Xin-Wei,DAI Yun-Yi,GUAN Xuan,WANG Xiao-Tong,ZHANG Chang-Guo.Primarily Research of Total Glycosides from Cornus Officinalis on Experimental Allergic Encephalomyelitis in Rats[J].Chinese Journal of Clinical Neurosciences,2009,17(2):118-122. |
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| Authors: | LI Yong SONG Xin-Wei DAI Yun-Yi GUAN Xuan WANG Xiao-Tong ZHANG Chang-Guo |
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| Institution: | LI Yong,SONG Xin-Wei,DAI Yun-Yi,GUAN Xuan,WANG Xiao-Tong,ZHANG Chang-Guo Department of Neurology,the Second Affiliated Hospital,Wenzhou Medical College,Wenzhou 325000,China |
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| Abstract: | Aim:To primarily investigate the effect of total glycosides from cornus officinalis(TGCO)on experimental allergic encephalomyelitis(EAE)in rats.Methods:Twenty four Wistar rats were randomly divided into three groups:Control group,EAE group,TGCC group.The diet,movement and body weight of Wistar rats were daily examined,CNS tissues were stained with Hematoxylin-eosin and Luxol Fast Blue. Results:Seven eights rats in EAE group demonstrated neurological signs of typical EAE with parenchymal infiltration and per... |
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| Keywords: | multiple sclerosis encephalomyelitis total glycosides from cornus officinalis experimental allergic encephalomyelitis |
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