| 舌癌周注射脂质体-阿霉素系统的药物分布规律的实验研究 |
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| 引用本文： | 陈绍维,潘剑,周琳,王昌美,温玉明.舌癌周注射脂质体-阿霉素系统的药物分布规律的实验研究[J].实用口腔医学杂志,2003,19(1):43-44. |
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| 作者姓名： | 陈绍维 潘剑 周琳 王昌美 温玉明 |
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| 作者单位： | 1. 中山大学附属二院口腔科,510120
2. 四川大学华西口腔医学院口腔颌面外科 |
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| 基金项目： | 卫生部科学基金资助项目 (编号 98- 1 - 2 2 1 )，福建省自然科学基金重点资助项目 (编号C0 2 2 0 0 0 2 ) |
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| 摘 要： | 目的：通过观察聚乙烯已二醇包被脂质体-阿霉素药物系统（pegylated liposmal doxorubicin，PLD）在舌癌模型的外周血及颈淋巴结内的药物浓度，探讨PLD治疗舌癌的价值。方法：建立舌癌淋巴转移模型的金黄地鼠40只，注射PLD后，分别观察外周血药浓度，淋巴结内药物浓度，并用荧光显微镜下观察。结果：PLD组的有铲药物浓度及持续作用时间明显优于阿霉素组。结论：PLD作为一种新兴的药物系统，在控制口腔癌转移方面是具有一定潜力的。
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| 关 键 词： | 舌癌 药物治疗 脂质体 阿霉素系统 |
| 文章编号： | 1001-3733(2003)-01-0043-02 |
| 修稿时间： | 2002年3月16日 |
Distribution of pegylated liposmal doxorubicin in animal model of tongue cancer |
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| Chen Shaowei,Pan Jian,Zhou Lin,et al..Distribution of pegylated liposmal doxorubicin in animal model of tongue cancer[J].Journal of Practical Stomatology,2003,19(1):43-44. |
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| Authors: | Chen Shaowei Pan Jian Zhou Lin |
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| Institution: | Chen Shaowei,Pan Jian,Zhou Lin,et al. The Department of Oral Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 610041 |
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| Abstract: | objective: To observe the distribution of pegylated liposmal doxorubicin(PLD) in animal model of tongue cancer. Methods: Tongue cancer model was established in 40 golden hamster, PLD or free doxorubicin at the dose of 9 mg/kg was injected perifocally into each of 20 mice, the concentration of the drugs in lypmph node and blood was measured with HPLC. Results: After injection of free ADM peak concerntration in blood was acheived in 3 h and in lymph nodes in 1 h, while after injection of PLD, that was in 16 and 6 h respectively. The concertration of PLD was heigher than that of ADM in both blood and lymph node from 16 or 6 h till 216 h after injetion.Conclusion: PLD can be regarded as valuable drug delivery system in the treatment of oral cancer. |
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| Keywords: | Tongue cancer Drug therapy Liposomes Doxorubicin |
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