Human milk and necrotizing enterocolitis |
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| Affiliation: | 1. Section of Neonatology, Rush University Children’s Hospital, 1653 W. Congress Pkwy, Pavilion 353, Chicago, Illinois 60612;2. Divisions of Neonatology & Pediatric Gastroenterology, Hepatology and Nutrition, University of California San Diego, Rady Children’s Hospital of San Diego, San Diego, California;1. Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Dr., RI 2500 Indianapolis, Indiana;2. Department of Pediatrics, Division of Neonatology, University of California Davis School of Medicine, Sacramento, California;1. Department of Pediatric Surgery, Vanderbilt University Medical Center, 2200 Children’s Way, Doctors Office Tower, Suite 7100, Nashville, Tennessee 37232;2. University of Arkansas, Fayetteville, Arkansas;3. Meharry Medical College School of Medicine, Nashville, Tennessee;4. Department of Neonatology and Division of Translational Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts;1. Department of Global Health Promotion, Tokyo Medical and Dental University (TMDU), Tokyo, Japan;2. Japan Support Center for Suicide Countermeasures, National Institute of Neurology and Psychiatry, Tokyo, Japan;3. Department of Social Medicine, National Research Institute for Child Health and Development, Tokyo, Japan |
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| Abstract: | NEC is a multifactorial disease that occurs when multiple risk factors and/or stressors overlap, leading to profound inflammation and intestinal injury. Human milk feedings, both from the infant’s mother and donor human milk, have been associated with reductions in NEC in preterm infants. This article will review the protective factors in human milk, clinical studies of human milk and NEC, and practices to enhance human milk use in neonatal intensive care units. |
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| Keywords: | Necrotizing enterocolitis Human milk Prematurity Donor milk |
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