| 木犀草素抗肿瘤血管生成作用机制的研究进展 |
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| 引用本文： | 熊娅,樊萍,蒋颖,李雪松,张泉,于萍.木犀草素抗肿瘤血管生成作用机制的研究进展[J].现代药物与临床,2023,38(5):1260-1265. |
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| 作者姓名： | 熊娅 樊萍 蒋颖 李雪松 张泉 于萍 |
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| 作者单位： | 绵阳市中心医院 消毒供应中心, 四川 绵阳 621000;绵阳市中心医院 肿瘤科, 四川 绵阳 621000;绵阳市人民医院 神经科, 四川 绵阳 621000;河北省中医院 中医内科, 河北 石家庄 050000 |
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| 基金项目： | 河北省中医药管理局科研计划项目（2018014） |
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| 摘 要： | 血管生成是恶性肿瘤的标志之一，涉及血管内皮细胞的增殖、迁移和细胞外基质分解等多种途径。血管内皮生长因子（VEGF）靶向抗肿瘤血管生成是临床肿瘤治疗的有效方法。木犀草素为黄酮类化合物，具有抗肿瘤活性，可通过抑制VEGF及相关信号通路、抑制磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路、抑制血管新生分子、抑制孕激素活性、靶向刺激Wnt信号通路、阻断生长停滞特异性蛋白6(Gas6)/受体酪氨酸激酶（Axl）信号通路而发挥抗肿瘤的血管生成作用。归纳了木犀草素抗肿瘤血管生成的作用机制，以期为木犀草素的临床应用提供参考。
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| 关 键 词： | 木犀草素 血管生成 血管内皮生长因子 PI3K/Akt信号通路 Wnt信号通路 Gas6/Axl信号通路 |
| 收稿时间： | 2023/2/14 0:00:00 |
Research progress on mechanism of luteolin against tumor angiogenesis |
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| XIONG Y,FAN Ping,JIANG Ying,LI Xue-song,ZHANG Quan,YU Ping.Research progress on mechanism of luteolin against tumor angiogenesis[J].Drugs & Clinic,2023,38(5):1260-1265. |
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| Authors: | XIONG Y FAN Ping JIANG Ying LI Xue-song ZHANG Quan YU Ping |
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| Institution: | Disinfection Supply Center, Mianyang Central Hospital, Mianyang 621000, China;Department of Oncology, Mianyang Central Hospital, Mianyang 621000, China;Department of Neurology, Mianyang People''s Hospital, Mianyang 621000, China; Department of Internal Medicine of Traditional Chinese Medicine, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050000, China |
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| Abstract: | Angiogenesis is one of the hallmarks of malignant tumors, which involves the proliferation, migration, and extracellular matrix decomposition of vascular endothelial cells. Targeted anti-angiogenesis of vascular endothelial growth factor (VEGF) is an effective method for clinical tumor treatment. Luteolin is a flavonoid compound with various anti-tumor activities. Luteolin plays an anti-tumor angiogenesis role by inhibiting VEGF and related signal pathways, PI3K/Akt signal pathway, inhibiting angiogenesis molecules, inhibiting progesterone activity, targeting the stimulation of Wnt signal pathway, blocking Gas6/Axl signal pathway. This paper summarizes the anti-tumor angiogenesis mechanism of luteolin in order to provide reference for clinical application of luteolin. |
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| Keywords: | luteolin angiogenesis VEGF PI3K/Akt signal pathway Wnt signal pathway Gas6/Axl signal pathway |
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