An update on biomarkers of necrotizing enterocolitis |
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| Institution: | 1. Department of Pediatric Surgery, Beatrix Children’s Hospital, University of Groningen, University Medical Center Groningen, The Netherlands;2. Department of Pediatric Pathology, Beatrix Children’s Hospital, University of Groningen, University Medical Center Groningen, The Netherlands;3. Department of Pediatric Neonatology, Beatrix Children’s Hospital, University of Groningen, University Medical Center Groningen, The Netherlands;4. Department of Pediatric Surgery, Medical University of Vienna, Austria;5. Research Core Unit for Pediatric Biochemistry and Analytics, Medical University of Vienna, Austria;1. Department of Pediatric Surgery, Medical University of Vienna, Vienna, Austria;2. Department of Pediatrics, Division of Neonatology, Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria;3. Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria;4. Department of General Surgery, Medical University of Vienna, Vienna, Austria;1. Department of Pediatric Surgery, Medical University of Vienna, Austria;2. Department of Pediatrics and Adolescent Medicine, Research Core Unit for Pediatric Biochemistry and Analytics, Medical University of Vienna, Austria;3. Department of Pediatrics, Division of Neonatology, Intensive Care and Neuropediatrics, Medical University of Vienna, Austria;1. Department of Pediatric Surgery, KK Women''s & Children''s Hospital, Singapore;2. Department of Pathology, KK Women''s & Children''s Hospital, Singapore;3. Institute of Molecular and Cell Biology, Singapore;4. Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore;5. Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto |
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| Abstract: | Necrotizing enterocolitis (NEC) remains a devastating surgical emergency with high morbidity and mortality in preterm infants. Slow but steady progress has been made in past years searching for novel biomarkers of NEC, for both surveillance and diagnostic purposes. This review primarily focuses on recent discoveries: clinical applications of different categories of biomarkers for surveillance, early diagnosis, and predicting severity and prognosis; and understanding of pathophysiological mechanisms as a basis to rationalize the search for ‘gut-associated specific biomarkers’ of NEC. An important next step is to collaborate with our industrial partners to develop point-of-care tests, and to discover novel and gut-associated specific biomarkers that can be used for surveillance and early diagnosis of NEC in routine clinical settings. |
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| Keywords: | Biomarkers Diagnosis Necrotizing enterocolitis Specific Surveillance |
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