Genetic variation of cytochrome P450 in Uyghur Chinese population |
| |
| Affiliation: | 1. Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden;2. Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia;3. Division of Clinical Pharmacology, Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, Badajoz, Spain;4. Department of Internal Medicine, Division of Clinical Pharmacology, Inha University Hospital, Incheon, South Korea |
| |
| Abstract: | Interindividual and interethnic variability of drug responses could be attributed to the differences of genetic polymorphisms in the drug metabolizing enzymes and transporters genes among the populations. Here we reviewed the studies of genetic variations in Uyghur Chinese of fifteen CYP450 genes including CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP2J2, CYP2W1, CYP3A4, CYP3A5, CYP4A11, and CYP17A1, which totally covered 277 variants. We also collected the data of 277 variants covered in our study in two extensive population sequencing projects, the International HapMap Project (Hap-Map) and the 1000 Genomes Project and compared them with the data of Uyghur Chinese. The results suggested that remarkable differences of variants allele frequencies of CYP450 genes were existed among Uyghur Chinese and other world populations and drug doses should be adjusted clinically in Uyghur in contrast to Han Chinese and Caucasians. |
| |
| Keywords: | Uyghur CYP450 Genetic polymorphisms Chinese Drug response |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
