首页 | 本学科首页   官方微博 | 高级检索  
     


Reconsidering olfactory bulb magnetic resonance patterns in Kallmann syndrome
Affiliation:1. Département universitaire d’anatomie de Rockefeller, UFR médecine Lyon-Est, 8, avenue Rockefeller, 69373 Lyon, France;2. Radiologie ostéo-articulaire et neuroradiologie, groupement hospitalier Edouard-Herriot, hospices civils de Lyon, 5, place d’Arsonval, 69437 Lyon, France;3. UFR médecine Lyon-Est, 8, avenue Rockefeller, 69373 Lyon, France;4. Abu-Haidar neuroscience institute, faculty of medicine, american university of Beirut, 11-0236 Riad-El-Solh, 1107 2020 Beirut, Lebanon;5. Fédération d’endocrinologie, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69500 Bron, France;6. Service de radiologie, centre hospitalier Lyon-Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France;7. Imagerie pédiatrique, hôpital couple-enfant, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France;8. Laboratoire de biochimie et génétique moléculaire, hôpital Cochin, APHP, université Paris-Descartes, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France;9. CREATIS, CNRS UMR 5220 Inserm U1044, université Lyon 1, 7, avenue Jean-Capelle, 69621 Villeurbanne, France;1. Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Daegu, Republic of Korea;2. Department of Neurosurgery, College of Medicine, Yeungnam University, Daemyungdong, Namku, Daegu, Republic of Korea;1. Faculty of Education, Laboratory of Chemistry, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, Japan;2. Department of Physical Chemistry, Showa Pharmaceutical University, Higashi-Tamagawagakuen 3-3165, Machida City, Tokyo 194-8543, Japan;3. Research Group of Chemistry, Division of Natural Science, Nara Women''s University, Kitauoyanishi-machi, Nara 630-8506, Japan;1. Centro de Biotecnología-FEMSA, Tecnologico de Monterrey, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, NL 64849, Mexico;2. Department of Chemical and Biomolecular Engineering, University of Houston, 4800 Calhoun Rd., Houston, TX 77004, United States;1. Department of Neurology, Medizinische Fakultät Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany;2. Institute for Clinical Chemistry, Medizinische Fakultät Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany;1. Department of Pharmacology & Therapeutics, University of Melbourne, Parkville, Australia;2. Department of Anatomical Pathology, The Alfred Hospital, Melbourne, Australia;3. Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Australia;4. Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia;5. Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, Australia
Abstract:ObjectiveThe aim of this retrospective study was to perform magnetic resonance imaging assessment of olfactory pathway and skull base abnormalities in Kallmann syndrome (KS) patients with hypogonadotropic hypogonadism and olfaction disorder.MethodsMagnetic resonance brain patterns were retrospectively studied in 19 patients clinically classified as KS. Qualitative assessment of olfactory bulb region comprised bulb atrophy and rectus and medial orbital gyrus ptosis; quantitative assessment measured olfactory fossa depth and width, sulcus depth and ethmoid angle. Results were compared to an age- and sex-matched control population (n = 19) with no impairment in the region of interest. Sixteen of the 19 KS patients were genetically screened for mutations associated with KS.ResultsOn the above qualitative criteria, 15 of the 19 patients presented either unilateral (n = 2) or bilateral (n = 13) olfactory bulb agenesis; 16 showed tract agenesis and 16 showed gyrus malformation (ptosis or absence). On the quantitative criteria, 18 of the 19 patients showed abnormal sulcus depth and/or olfactory fossa malformation and/or abnormal ethmoid angle.ConclusionThe presence of malformation abnormalities in the olfactory fossae of 18 of the 19 patients appears to be a key factor for etiological diagnosis of hypogonadotropic hypogonadism, and should enable targeted study of genes involved in KS.
Keywords:Kallmann syndrome  Hypogonadism  Olfactory bulb  Olfaction Disorder  Magnetic resonance imaging  Syndrome de Kallmann  Hypogonadisme  Bulbe olfactif  Anosmie  Imagerie par résonnance magnétique
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号