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Prophylactic and early targeted treatment of patent ductus arteriosus
Affiliation:1. Department of Neonatology, The James Cook University Hospital, Middlesbrough, UK;2. Durham University, Stockton-on-Tees, UK;3. Department of Paediatrics and Neonatology, University Hospital of North Tees, Stockton-on-Tees, UK;1. Durham University, Stockton-on-Tees, UK;2. Department of Pediatrics, University of Toronto, Toronto, Canada;1. Department of Pediatrics, Children''s Mercy Hospitals & Clinics, University of Missouri, Kansas City School of Medicine, Kansas City, MO, USA;2. Department of Pediatrics, Monroe Carell Jr. Children''s Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN, USA;3. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA;4. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;5. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA;6. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA;1. Fetal and Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, Stollery Children''s Hospital, Edmonton, Alberta, Canada;2. Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil;1. Department of Pediatrics, Seoul National University–Seoul Metropolitan Government Boramae Medical Center, Seoul, South Korea;2. Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea;3. Department of Biostatistics, Seoul National University–Seoul Metropolitan Government Boramae Medical Center, Seoul, South Korea;4. Department of Pediatrics, Korea Ansan Hospital, Gyunggi-do, South Korea;5. Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea
Abstract:Treatment of a haemodynamically significant patent ductus arteriosus (PDA) in the very preterm infant has been an accepted approach for several decades. However, the rationale for closure of PDA has recently been challenged due to reports of success with conservative approaches and the lack of evidence for longer-term benefits from treatment. In this article, we address an approach to assess treatment of those babies most likely to benefit.
Keywords:Preterm  Patent ductus arteriosus  Early targeted treatment  Prophylactic treatment  Ibuprofen  Indomethacin
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