Non-invasive assessment of coronary artery geometry using coronary CTA |
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| Affiliation: | 1. University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands;2. University of Groningen, University Medical Center Groningen, Department of Radiology, The Netherlands;3. University of Twente, Technical Medicine Faculty, The Netherlands;4. University of Groningen, University Medical Center Groningen, Cardiology, The Netherlands;1. Children''s Heart Clinic at Children''s Hospitals and Clinics of Minnesota, USA;2. Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN, USA;3. University of British Columbia, St. Paul''s Hospital, Vancouver, BC, Canada;4. University of Cincinnati, Cincinnati, OH, USA;5. Royal Brompton Hospital, Chelsea, London, UK;6. Southhampton General Hospital, Southampton, UK;7. The Heart Center at Boston Children''s Hospital, Boston, MA, USA;8. Ann and Robert H. Lurie''s Children''s Hospital, Chicago, IL, USA;9. Medical University of South Carolina, Charleston, SC, USA;1. Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;2. Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA;3. Department of Health Services, University of Washington, Seattle, WA, USA;4. Saint Joseph''s Hospital, Atlanta, GA, USA |
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| Abstract: | AimTo assess the association of coronary artery geometry with the severity of coronary artery disease (CAD).Methods73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models.ResultsOverall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001).ConclusionCoronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis. |
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| Keywords: | Coronary artery disease Coronary computed tomography angiography Curvature Tortuosity Coronary artery plaque Atherosclerosis |
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