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Barrett's esophagus: a comprehensive review and update
Affiliation:1. Surgical Pathology Division, Department of Laboratory, A. Manzoni Hospital, Lecco, Italy;2. Anatomic Pathology Unit, Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy;1. Department of Pathology, University of Michigan, 5231B Medical Science I, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109-5602, USA;2. Department of Pathology, University of Michigan, 5220 Medical Science I, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109-5602, USA;1. Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands;3. Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, the Netherlands
Abstract:Barrett's esophagus (BE) is a known precursor to esophageal adenocarcinoma. In the United States, a prevalence of up to 25% is reported in high risk populations and it is identified in about 5% of patients with gastroesophageal reflux disease (GERD). The diagnosis of BE requires endoscopically identifying columnar (“salmon colored”) mucosa, taking biopsies from targeted areas and then confirming histologically. The American College of Gastroenterologists updated its criteria in 2016, introducing a length requirement. This brief review addresses diagnosis of BE and its various associated challenges; identifying dysplasia, grading it, and management.
Keywords:Barrett's esophagus  dysplasia  gastroesophageal junction  management  z-line
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