Stem cell therapy in necrotizing enterocolitis: Current state and future directions |
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| Institution: | 1. UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK;2. Faculty of Medicine, University of Southampton, Southampton, UK;1. Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, IN;2. The Indiana University School of Medicine, Indianapolis, Indianapolis, IN;3. The Indiana University School of Medicine, South Bend, South Bend, IN |
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| Abstract: | Stem cell therapy is a promising treatment modality for necrotizing enterocolitis. Among the many promising stem cells identified to date, it is likely that mesenchymal stem cells will be the most useful and practical cell-based therapies for this condition. Using acellular components such as exosomes or other paracrine mediators are promising as well. Multiple mechanisms are likely at play in the positive effects provided by these cells, and further research is underway to further elucidate these effects. |
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| Keywords: | Necrotizing enterocolitis Stem cell therapy Premature Neonatal Intestine Ischemia |
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