| 2-吲哚醛西佛碱化合物的合成及其抗癌活性研究 |
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| 引用本文： | 徐莉,徐世平. 2-吲哚醛西佛碱化合物的合成及其抗癌活性研究[J]. 药学学报, 2000, 35(4): 269-272 |
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| 作者姓名： | 徐莉 徐世平 |
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| 作者单位： | 中国医学科学院、中国协和医科大学药物研究所,北京,100050 |
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| 摘 要： | 目的：合成一系列吲哚-2-位西佛碱衍生物，通过药理筛选寻找具有抗癌活性的化合物。方法：通过亲核取代、还原、氧化、亲核加成等反应得到目的化合物。结果：设计合成了22个吲哚-2-位西佛碱新化合物，药理筛选结果显示2个化合物(5,14)对KB癌细胞株有抑制作用。结论：药理筛选结果表明，一些化合物显示了一定的抗癌活性，值得进一步研究。
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| 关 键 词： | 吲哚衍生物 西佛碱 抗癌活性 |
| 修稿时间： | : |
STUDIES ON THE SYNTHESIS AND ANTICANCER ACTIVITY OF SCHIFF BASES OF 2-INDOLALDEHYDE |
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| Xu Li,Xu Shiping. STUDIES ON THE SYNTHESIS AND ANTICANCER ACTIVITY OF SCHIFF BASES OF 2-INDOLALDEHYDE[J]. Acta pharmaceutica Sinica, 2000, 35(4): 269-272 |
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| Authors: | Xu Li Xu Shiping |
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| Abstract: | AIM: A series of Schiff bases of 2 indolaldehyde were synthesized in order to find compounds with anticancer or other biological activities by screening in vitro . METHODS: Electrophilic substitution, reduction, oxidation and nucleophilic addition reaction were used in the synthesis of title compounds. RESULTS: Twenty two compounds were synthesized. The structures of the derivatives were confirmed by 1HNMR, MS and elemental analysis data. Compounds 5 and 14 showed inhibitory effects on KB cell line in vitro . CONCLUSION: Some compounds showed anticancer activities and it is worth further studying. |
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| Keywords: | indole derivatives Schiff base anticancer activity |
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