红景天苷对异丙肾上腺素致大鼠急性心肌缺血的影响

目的：研究红景天苷对异丙肾上腺素（ISO）致大鼠急性心肌缺血的影响。方法：连续两天皮下给予ISO,诱导大鼠急性心肌缺血模型,观察红景天苷对大鼠心电图的影响,检测血清中乳酸脱氢酶（LDH）、肌酸激酶（CK）、超氧化物歧化酶（SOD）和丙二醛（MDA）的含量,测定心肌梗死面积。结果：红景天苷（6.0、12.0、24.0mg/kg）能有效对抗心电图T波和J点的升高,显著降低血清中LDH、CK和MDA的含量,升高血清中SOD的含量（P〈0.01,P〈0.05vs模型）,明显减少心肌梗死面积（P〈0.01vs模型）。结论：红景天苷对ISO所致大鼠急性心肌缺血有一定的保护作用。

Protective effects of salidroside on isoprenaline induced myocardial ischemia in rats

AIM： To study the protective effects of salidroside on isoprenaline induced acute myocardial ischemia in rats. METHODS： The model was established by subcutaneous injection （ s. c. ） of isoprenaline. The change of Electrocardiogram （ECG） was observed. The levels of LDH, CK, SOD and MDA in serum were measured and the cardiac infarction area was examined. RESULTS： Salidrode （6,12,24 mg/kg） could effectively reverse the evident changes of T wave and J point induced by isoproterenol, notably decrease the levels of LDH, CK and MDA and increase the levels of SOD in serum（ P 〈 0.01, P 〈 0.05 vs Model）, and significantly reduce the cardiac infarction area （P 〈 0.01）. CONCLUSION： Salidroside protects rats from acute myocardial ischemia.