大鼠小肠广泛切除术后血浆谷氨酰胺水平的动态变化

动态观察了大鼠８０％小肠切除后血浆谷氨酰胺浓度变化。发现术后４、７、１０、１４ｄ血浆谷氨酰胺轻度上升，与正常组比较，均无显著差异。Ｐ＞０．０５。讨论了谷氨酰胺对肠粘膜上皮细胞的增殖作用。认为小肠广泛切除术后可适量给予谷氨酰胺以促进残管粘膜上皮细胞的代偿性增殖反应。

CHANGES OF PLASMA CLUTAMINE LEVEL IN RATS AFTER MASSIVE SMALL BOWET RESECTION

ecent studies demostrated that glutamine is the principal fuel userl by the gastrointestinaltract,and the small intestine is the main organ of glutamine,consumption. This study wasdesiqned to investigate the series changes of plasma glutamine in rats after massive small bowelresection, and explored the relation between the clianges of cnculating glutamine and the remnantintestinal mucosa adaptatior. In the lst to 14th postoperative days,a high fasting level of plasmaglutamine was found with the highest value on the 7th postoperative day. However, there was nostatistical difference in comparison with the contml group(P>0.05).Thls paper discussed thatglutamine has trophic effect on the intestinal mucosa and suggested that glutamine may havewidespread application in the repair of remnant gastrointestinal tissue after massivc small bewelresection.