47例99mTc-ECD脑血流灌注显像结果分析

目的：评价脑血流灌注显像在各种神经系统疾病中诊断价值。方法：对４７例脑外伤、脑血管病等神经系统疾病进行９９ｍＴｃ标记双半胱乙酯（９９ｍＴｃＥＣＤ）脑血流灌注断层显像，部分检查和ＣＴ进行比较。结果：１０例轻度脑外伤和４例脑挫裂伤显示局部脑血流量（ｒＣＢＦ）减少，在１５例轻度脑外伤，单光子断层成像（ＳＰＥＣＴ）和ＣＴ诊断阳性率分别为４０％和１３％；１１例脑血管病中９例显示病灶处ｒＣＢＦ减少，其中５例出现交叉性神经功能联系中断。在１１例脑血管病中ＳＰＥＣＴ和ＣＴ阳性率分别为８２％和７３％。另有老年性痴呆、癫痫和偏头痛各１例显示ｒＣＢＦ异常。结论：９９ｍＴｃＥＣＤ脑血流灌注显像对中枢神经疾病的诊断和研究有重要意义。

ANALYSIS OF 99 m Tc ECD BRAIN PERFUSION IMAGING IN 47 PATIENTS

Objective:To evaluate the clinical value of 99 m Tc ethyl cystine dimer( 99 m Tc ECD) brain perfusion in single photon emission computed tomography(SPECT) in patients with central nervous diseases.Methods:Forty seven patients were examined with 99 m Tc ECD SPECT,and the imaging findings were compared with X ray CT examination.Results:The SPECT brain scan showed decreased blood flow in 10 patients with mild traumatic brain injury and four patients with cerebral contusion.The sensitivity of SPECT and X ray CT in 15 patients with mild traumatic brain injury was 40% and 13% respectively.In the cerebrovascular disease,nine of 11 patients showed regional decreased cerebral blood flow and 5 appeared crossed diaschisis.Sensitvity of SPECT and X ray CT in 11 patients with the cerebrovascular disease was 82% and 73%.And each one of Alzhemer's disease,seizure and migraine disorders showed abnormal perfusion typically.Conclusion: 99 m Tc ECD brain perfusion SPECT is a useful method for study and diagnosis in patients with central nervous diseases.